SerpinPC for Hemophilia
(PRESent-6 Trial)
Trial Summary
Do I have to stop taking my current medications?
The trial requires that you stop taking anticoagulant or antiplatelet drugs.
What data supports the idea that SerpinPC for Hemophilia is an effective treatment?
The available research shows that targeting natural serpins, which are proteins that help control bleeding, can reduce bleeding in people with hemophilia. This suggests that SerpinPC, which works by blocking these proteins, could be an effective treatment. While the research doesn't directly compare SerpinPC to other treatments, it highlights the potential of using serpins to balance blood clotting in hemophilia, offering a promising alternative to traditional therapies that require frequent injections.12345
What safety data is available for SerpinPC in treating hemophilia?
Is the drug SerpinPC a promising treatment for hemophilia?
What is the purpose of this trial?
The purpose of the study is to evaluate the efficacy, safety, tolerability and pharmacokinetic (PK) profile of prophylactic SerpinPC in participants with hemophilia
Eligibility Criteria
This trial is for males aged 12-65 with Hemophilia who have already completed a SerpinPC clinical trial and were compliant. They must be able to give informed consent, or if underage, obtain parental/guardian consent.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive SerpinPC 1.2 mg/kg subcutaneous injection every 2 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Open-label extension
Participants continue to receive SerpinPC to observe long-term safety and efficacy
Treatment Details
Interventions
- SerpinPC
Find a Clinic Near You
Who Is Running the Clinical Trial?
ApcinteX Ltd
Lead Sponsor
Centessa Pharmaceuticals plc
Industry Sponsor