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DNX-2440 for Liver Metastases from Colorectal Cancer
Study Summary
This trial is testing an experimental virus called DNX-2440 to see if it is safe and effective in treating patients with liver metastasis who are scheduled for surgery.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- You have liver cancer that has been treated with more than 12 cycles of systemic chemotherapy.You are currently taking medication that weakens your immune system.Your lab tests show that your organs are not working well enough.The cancer has come back in the liver.You have been diagnosed with neuroendocrine tumor that has spread to the liver.Your liver enzymes (AST and/or ALT) or total bilirubin are more than 5 times the normal levels.You have cancer that has spread to your liver from certain types of cancer.You have two or more tumors in your liver.You are eligible for surgery with the intent to cure the disease.If you are eligible for a specific treatment based on your gene mutations, you must have finished that treatment.You are allowed to have chemotherapy before surgery.
- Group 1: Dose-level 1
- Group 2: Dose-level 2
- Group 3: Dose-level 3
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is the research team currently searching for participants?
"Yes, the information on clinicaltrials.gov verifies that this trial is actively recruiting patients. Initially posted on February 15th 2021, it has been recently updated March 28th 2022 and seeks 30 participants from a single research site."
Has DNX-2440 obtained regulatory clearance from the FDA?
"The safety of DNX-2440 was judged to be a 1 rating due to the limited evidence that exists in Phase 1 trials, which demonstrate only initial indications of efficacy and safety."
How many people are currently participating in this research project?
"Affirmative, clinicaltrials.gov shows that this clinical trial is actively collecting participants since it was first posted on February 15th 2021, and the most recent update occurred March 28th 2022. A total of 30 patients are required for this single-site research project."
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