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rTMS for Anxiety Disorders

Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up during session (approx. 45 minutes)
Awards & highlights
No Placebo-Only Group

Study Summary

This trial is exploring if a device that changes brain activity can help people with anxiety better cope with fear or anxious situations. The study involves 3 visits, during which participants will do tasks while their brain activity is measured. If you qualify and participate, you can expect the visits to last 2-4 hours each.

Who is the study for?
This trial is for adults aged 18-65 who are fluent in English, currently seeking mental health treatment, and diagnosed with an anxiety disorder or related condition. It's not suitable for those on certain medications, pregnant individuals, people with metal implants (due to MRI), history of seizures or severe brain injury, substance abuse issues, psychotic disorders or bipolar mania.Check my eligibility
What is being tested?
The study tests if repetitive Transcranial Magnetic Stimulation (rTMS) can influence coping mechanisms in anxious situations. Participants will undergo rTMS and perform tasks that measure their reaction to emotional stimuli over three visits lasting up to four hours each at the Medical University of South Carolina.See study design
What are the potential side effects?
While this study isn't a treatment trial and focuses on reactions to emotional stimuli post-rTMS application, potential side effects from rTMS may include discomfort at the stimulation site, headache, lightheadedness or seizures in very rare cases.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~during session (approx. 45 minutes)
This trial's timeline: 3 weeks for screening, Varies for treatment, and during session (approx. 45 minutes) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Fear-Potentiated Startle Reflex
Change in Speed to Initiate Avoidance Behavior
Secondary outcome measures
Change in Approach/ Avoidance Conflict Electroencephalography
Change in Difficulty of Avoiding Task-Based Aversive Exposure
Change in Escape/ Avoidance Electroencephalography
+4 more
Other outcome measures
Task-Related Brain Activation

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Neurostimulation GroupExperimental Treatment1 Intervention
On one study day, participants will complete experimental tasks during functional magnetic resonance imaging. On two other study days, participants will complete tasks before and after receiving repetitive transcranial magnetic stimulation (rTMS). All participants will receive rTMS to ventromedial prefrontal cortex on one study day, and to pre-supplementary motor area on another study day. Two stimulation procedures will be used, one for ventromedial prefrontal cortex and one for pre-supplementary motor area. For both targets, 3 sessions of 600 pulses at 110% of resting motor threshold will be presented over 30 minutes. For ventromedial cortex, a session will involve intermittent theta burst triplets at 50 Hz for 2 seconds and repeated every 10 seconds for a total of 190 seconds. For pre-supplementary motor area, a session will involve continuous theta burst presented in 3-pulse bursts with 15 pulses/ sec.
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation (rTMS)
Completed Phase 2

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
924 Previous Clinical Trials
7,369,591 Total Patients Enrolled
14 Trials studying Anxiety Disorders
983 Patients Enrolled for Anxiety Disorders
National Institute of Mental Health (NIMH)NIH
2,761 Previous Clinical Trials
2,459,723 Total Patients Enrolled
155 Trials studying Anxiety Disorders
65,338 Patients Enrolled for Anxiety Disorders

Media Library

Repetitive Transcranial Magnetic Stimulation (rTMS) Clinical Trial Eligibility Overview. Trial Name: NCT04824105 — N/A
Anxiety Disorders Research Study Groups: Neurostimulation Group
Anxiety Disorders Clinical Trial 2023: Repetitive Transcranial Magnetic Stimulation (rTMS) Highlights & Side Effects. Trial Name: NCT04824105 — N/A
Repetitive Transcranial Magnetic Stimulation (rTMS) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04824105 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the goals of this medical trial?

"The primary objectives of this clinical trial are to assess the transformation in speed when initiating an avoidance response within a 30 minute duration. Secondary endpoints include analysis into how EEG reflects approach/avoidance conflict and alterations in task-related cardiac changes as participants face off against virtual predators or view unpleasant images."

Answered by AI

What is the current participant count for this trial?

"Affirmative, according to clinicaltrials.gov the trial is still open for applicants. It was first posted on June 26th 2021 and has since been updated January 10th 2022. The research project needs 80 participants from a single location."

Answered by AI

Does this medical experiment accept participants aged under 55?

"The parameters for enrolment in this medical trial are a minimum age of 18 and upper limit of 65 years old."

Answered by AI

Is it feasible for me to enroll in this clinical trial?

"A cohort of 80 participants aged 18-65 with anxiety disorders that are currently receiving mental health treatment are being sought for this trial."

Answered by AI

Is this research endeavor currently seeking participants?

"Affirmative, the information on clinicaltrials.gov attests that this medical study is actively recruiting patients, having been initially posted on June 26th 2021 and most recently updated on January 10th 2022. The trial aims to recruit 80 individuals from a single facility."

Answered by AI

Who else is applying?

What state do they live in?
How old are they?
18 - 65
What site did they apply to?
Medical University of South Carolina
What portion of applicants met pre-screening criteria?
Met criteria
~33 spots leftby Dec 2025