Cytosponge for EoE
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method to examine the esophagus in children and teens with eosinophilic esophagitis (EoE), a condition that causes painful swelling in the esophagus. Instead of the usual scope and biopsy, the trial uses a small, swallowable sponge capsule called the CytospongeTM. The researchers aim to determine if this new method is accurate, safe, and easier for follow-ups. Children and teens diagnosed with EoE, who can swallow a small capsule and are already scheduled for an endoscopy, might be suitable for this trial. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could simplify and improve future EoE diagnostics.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you are on anticoagulation therapy, you may not be eligible to participate.
What prior data suggests that the CytospongeTM is safe for use in older children and adolescents with EoE?
Research shows that the Cytosponge, a small sponge inside a capsule, is generally safe and easy to use for collecting cells from the esophagus. Studies have found that healthcare settings can safely use it, offering a less invasive option compared to traditional methods like endoscopy. Although a small chance exists for minor issues like tiny tears in the esophagus, these are rare. Most people undergo the procedure without major problems. Overall, the Cytosponge provides a safe way to sample esophageal cells.12345
Why are researchers excited about this trial?
Researchers are excited about using the Cytosponge TM for sampling the esophageal mucosa in children and adolescents with eosinophilic esophagitis (EoE) because it offers a non-invasive and potentially more comfortable alternative to traditional biopsies. Unlike standard endoscopic biopsies that require sedation and can be quite uncomfortable, the Cytosponge TM is a small, expandable sponge that is swallowed and then retrieved, offering a simpler and less distressing experience. This method could make it easier to monitor EoE by providing a more convenient way to collect tissue samples, potentially leading to more frequent monitoring and better disease management.
What evidence suggests that the CytospongeTM is effective for Eosinophilic Esophagitis?
Research shows that the Cytosponge, a new tool for collecting cells from the esophagus, could help diagnose conditions like Eosinophilic Esophagitis (EoE). Studies have found that the Cytosponge successfully collects samples from the esophagus in over 90% of cases in some trials. It offers a simpler and less invasive option compared to traditional methods like endoscopy. In certain instances, the Cytosponge has collected samples in 75% of patients. Although still under study, these results suggest it might effectively monitor EoE in children and teens. Participants in this trial will have samples collected using the Cytosponge, and researchers will compare its effectiveness to traditional biopsy techniques.16789
Who Is on the Research Team?
Margaret Marcon, MD
Principal Investigator
The Hospital for Sick Children
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo the Cytosponge procedure and traditional endoscopy for histological comparison
Follow-up
Participants are monitored for safety and effectiveness after the procedures
What Are the Treatments Tested in This Trial?
Interventions
- Using a swallowed expanding sponge (Cytosponge TM) to obtain sampling of the esophageal musosa
Find a Clinic Near You
Who Is Running the Clinical Trial?
The Hospital for Sick Children
Lead Sponsor