Exercise for Breast Cancer Cognitive Function
(BRAIN Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It is best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Aerobic Exercise Training for improving cognitive function in breast cancer patients?
Research suggests that aerobic exercise may improve cognitive function in breast cancer patients, as it has been associated with better attention, memory, and processing speed. Studies have shown that physical activity and cardiorespiratory fitness are linked to improved cognitive abilities in postmenopausal women with breast cancer.12345
Is aerobic exercise safe for breast cancer patients?
How does aerobic exercise training differ from other treatments for cognitive function in breast cancer patients?
Aerobic exercise training is unique because it is a non-drug approach that may improve cognitive function in breast cancer patients by enhancing physical activity and cardiorespiratory fitness, which are linked to better cognitive outcomes. Unlike other treatments, it is a low-cost, adaptable method that can be easily integrated into daily life and has shown promise in improving cognitive function in both healthy older adults and those with cognitive impairments.12345
What is the purpose of this trial?
This phase II trial tests whether an exercise intervention works to improve cognitive function in breast cancer survivors. Many breast cancer survivors report cancer-related cognitive impairment, which this has recently become a priority in clinical research due to its dramatic impact on daily functioning, quality of life, and long-term health. Aerobic exercise has the potential to improve cognitive function and brain health in older adults and is recommended as a safe, tolerable, and accessible complementary therapy for breast cancer survivors. This study aims to understand the effects of physical activity compared with health education on memory, attention, and brain health in women with breast cancer. Study findings may help researchers design more programs that can improve memory, attention, and brain health in other women with breast cancer.
Research Team
Diane K. Ehlers, Ph.D.
Principal Investigator
Mayo Clinic
Eligibility Criteria
This trial is for post-menopausal women who had a first, primary diagnosis of Stage I-IIIa breast cancer, are sedentary, and have completed their main treatments between 3-24 months ago. They must be cleared by a physician to exercise and agree to randomization. Excluded are those with second cancer diagnoses (except certain skin cancers), significant cognitive impairment, recent or ongoing chemotherapy or radiation therapy, neurological disorders, planned surgeries during the study period, or contraindications to MRI.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants are randomized to either a community-based aerobic exercise intervention or health education program for 6 months
Follow-up
Participants are monitored for cognitive function and other health outcomes after the intervention
Treatment Details
Interventions
- Aerobic Exercise Training
- Health Education
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Nebraska
Lead Sponsor
Mayo Clinic
Lead Sponsor
National Cancer Institute (NCI)
Collaborator