Paid Clinical Trials in Boston, MA
Here are the 6 most popular medical studies in paid studies boston
Deoxycholic Acid vs Polidocanol for Neurofibromatosis
This trial will look at if Kybella & Asclera injections are effective & safe for treating Neurofibromatosis Type 1 Cutaneous Neurofibromas. Patients will have one site treated & one as a control.
Supramaximal resection for Brain Cancer
A greater extent of resection of the contrast-enhancing (CE) tumor part has been associated with improved outcomes in high-grade glioma patients. Recent results suggest that resection of the non-contrast-enhancing (NCE) part might yield even better survival outcomes (supramaximal resection, SMR). Therefore, this study evaluates the efficacy and safety of SMR with and without mapping techniques in HGG patients in terms of survival, functional, neurological, cognitive, and quality of life outcomes. Furthermore, it evaluates which patients benefit the most from SMR, and how they could be identified preoperatively. This study is an international, multicenter, prospective, 2-arm cohort study of observational nature. Consecutive HGG patients will be operated with supramaximal resection or maximal resection at a 1:3 ratio. Primary endpoints are: 1) overall survival and 2) proportion of patients with NIHSS (National Institute of Health Stroke Scale) deterioration at 6 weeks, 3 months, and 6 months postoperatively. Secondary endpoints are 1) residual CE and NCE tumor volume on postoperative T1-contrast and FLAIR MRI scans 2) progression-free survival; 3) onco-functional outcome, and 4) quality of life at 6 weeks, 3 months, and 6 months postoperatively. The study will be carried out by the centers affiliated with the European and North American Consortium and Registry for Intraoperative Mapping (ENCRAM).
Phase 3 Clinical Trials
View 91 phase 3 medical studies.
GLP-1 Receptor Agonist
CagriSema, Semaglutide, and Cagrilintide for Type 2 Diabetes
“ IAM over weight and wanted to try the obesity study for my health. I am on a couple of diabetes medications plus Victoza, and it doesn't seem to help.”
Clinical Trials With No Placebo
View 91 medical studies that do not have a placebo group.
Tumor biopsy for Glioblastoma
There is no consensus on the optimal treatment of patients with high-grade glioma, especially when patients have limited functioning performance at presentation (KPS ≤70). Therefore, there are varied practice patterns around pursuing biopsy, resection, or palliation (best supportive care). This study aims to characterize the impact of palliative care versus biopsy versus resection on survival and quality of life in these patients. Also, it will aim to determine if there is a subset of patients that benefit the most from resection or biopsy, for which outcome, and how they could be identified preoperatively. This study is an international, multicenter, prospective, 3-arm cohort study of observational nature. Consecutive HGG patients will be treated with palliative care, biopsy, or resection at a 1:3:3 ratio. Primary endpoints are: 1) overall survival, and 2) quality of life at 6 weeks, 3 months and 6 months after initial presentation based on the EQ-5D, EORTC QLQ C30 and EORTC BN 20 questionnaires. Total duration of the study is 5 years. Patient inclusion is 4 years, follow-up is 1 year.
EMA+Maintenance TMS for Depression
This trial evaluates using EMA to schedule maintenance TMS sessions for MDD patients who responded to initial TMS. Weekly PHQ-9 scores will be monitored and TMS sessions offered when symptoms worsen. The trial lasts one year with TMS as adjunct to usual MDD treatments.
Controls for Traumatic Brain Injury
Rebion has developed a device, the Rebion trauma tool (referred to as the head and intraocular trauma tool, or "HITT"), that detects ocular fixation and alignment using a binocular retinal scan. Preliminary data obtained from hospitalized patients with a clinically-confirmed traumatic brain injury (TBI) and uninjured controls indicates that the device can detect changes in ocular fixation, alignment, and saccades that are related to brain injury. This study seeks to evaluate the ability of the Rebion trauma tool to assess perturbations in eye movements resulting from TBI. The study will enroll 60 TBI patients and 20 controls.
View More Paid Studies Boston Trials
See another 71 many medical studies focused on paid studies boston.
SENSE-plus: The Supporting and Enhancing NICU Sensory Experiences 2nd Edition (SENSE II) program +1 More