Group 1 for Total Knee Arthroplasty (TKA)

Phase-Based Progress Estimates

Effectiveness

Safety

Total Knee Arthroplasty (TKA)

Dexamethasone 4mg - Drug

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Eligibility

18+

All Sexes

What conditions do you have?

Select

Eligibility

18+

All Sexes

What conditions do you have?

Select

Study Summary

This trial is testing whether a lower dose of the steroid dexamethasone given during surgery can reduce postoperative pain and the need for opioids without increasing other complications.

Treatment Effectiveness

Effectiveness Progress

3 of 3

This is further along than 93% of similar trials

Other trials for Total Knee Arthroplasty (TKA)

Exparel

MOVE

TKA with Neurectomy

Study Objectives

1 Primary · 6 Secondary · Reporting Duration: <30 days after surgical intervention, document any readmissions to the hospital or complications that occur within 30 days from the day of surgery

48-hours postoperative (after surgical intervention)

Opioid consumption

Day 30

Number of participants with complications (such as readmission to hospital) up to 30 days after surgical intervention

Day 1

Postoperative pain scores at rest and with activity

Day 1

Sleeplessness/insomnia

Day 1

Postoperative nausea and vomiting

Day 30

Postoperative Blood glucose levels and insulin use

Day 30

Length of stay

Trial Safety

Safety Progress

3 of 3

This is further along than 85% of similar trials

Other trials for Total Knee Arthroplasty (TKA)

Exparel

MOVE

TKA with Neurectomy

Trial Design

3 Treatment Groups

Group 1

1 of 3

Group 2

1 of 3

Group 3

1 of 3

Active Control

429 Total Participants · 3 Treatment Groups

Primary Treatment: Group 1 · No Placebo Group · Phase 4

Group 1

Drug

ActiveComparator Group · 1 Intervention: Dexamethasone 4mg · Intervention Types: Drug

Group 2

Drug

ActiveComparator Group · 1 Intervention: Dexamethasone 8 Mg/mL Injectable Suspension · Intervention Types: Drug

Group 3

Drug

ActiveComparator Group · 1 Intervention: Dexamethasone 16mg · Intervention Types: Drug

Trial Logistics

Trial Timeline

Approximate Timeline

Screening: ~3 weeks

Treatment: Varies

Reporting: <30 days after surgical intervention, document any readmissions to the hospital or complications that occur within 30 days from the day of surgery

Who is running the clinical trial?

Rush University Medical CenterLead Sponsor

379 Previous Clinical Trials

150,668 Total Patients Enrolled

5 Trials studying Total Knee Arthroplasty (TKA)

1,424 Patients Enrolled for Total Knee Arthroplasty (TKA)

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:

I am over 18 years old.

are twice as likely to get an infection as those going home the same day

About The Reviewer

Michael Gill - B. Sc.

First Published: October 25th, 2021

Last Reviewed: October 13th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References