Lidocaine vs Bupivacaine for Postoperative Pain
Trial Summary
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the drug Bupivacaine for postoperative pain?
Research shows that Bupivacaine, also known as Marcaine or Sensorcaine, is effective in managing postoperative pain due to its long-lasting effects and favorable safety profile. It has been used successfully in surgeries like breast reduction and obstetrical procedures, providing good pain relief with minimal side effects.12345
Is bupivacaine generally safe for use in humans?
How do lidocaine and bupivacaine differ in managing postoperative pain?
What is the purpose of this trial?
In this research study, we want to learn more about the impact of two different local anesthetics (bupivacaine and lidocaine) on patient experience following orthognathic (jaw) surgery. Both anesthetics are within the standard of care for dental and orthognathic procedures, but can vary in how quickly they take action and how long they last. This study will provide us with a greater understanding of how anesthetic choice affect patient outcomes, and how we can strive to make these outcomes as favorable as possible.
Research Team
Mark A Green, DDS, MD
Principal Investigator
Boston Children's Hospital, Department of Plastic and Oral Surgery
Eligibility Criteria
This trial is for individuals aged 15-35 undergoing jaw surgery at Boston Children's Hospital. It aims to compare the effects of two local anesthetics on patient recovery.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo orthognathic surgery with administration of bupivacaine and lidocaine as local anesthetics
Immediate Postoperative Assessment
Participants are assessed for numbness, light touch perception, temperature sensation, and pain approximately one hour and four hours after surgery
Follow-up
Participants are monitored for safety and effectiveness, including assessments of numbness, light touch perception, temperature sensation, and pain one week after surgery
Treatment Details
Interventions
- Bupivacaine
- Lidocaine
Bupivacaine is already approved in United States, European Union, Canada for the following indications:
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
Find a Clinic Near You
Who Is Running the Clinical Trial?
Boston Children's Hospital
Lead Sponsor