75 Participants Needed

OPM MEG Brain Activity Mapping

AN
AM
AC
Overseen ByAllison C Nugent, Ph.D.
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: National Institute of Mental Health (NIMH)
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial is testing a new sensor called OPM that measures brain activity by detecting magnetic fields. These sensors can be placed directly on the scalp and offer advantages over traditional methods. It targets healthy adults aged 18-65 who have had an MRI scan. The sensors are placed on a cap and can accurately measure the brain's magnetic fields.

Will I have to stop taking my current medications?

The trial protocol does not specify whether you need to stop taking your current medications.

Is OPM MEG safe for use in humans?

The research on OPM MEG (Optically Pumped Magnetometer Magnetoencephalography) suggests it is generally safe for use in humans. Studies have shown that OPM MEG systems can operate effectively in various environments, and they do not require the use of liquid helium, which is needed for traditional MEG systems, making them safer and more flexible.12345

How does the OPM MEG Brain Activity Mapping treatment differ from other treatments for brain activity mapping?

The OPM MEG Brain Activity Mapping treatment is unique because it uses optically-pumped magnetometers (OPMs) instead of traditional superconducting quantum interference devices (SQUIDs). OPMs do not require cryogenic cooling, allowing them to be placed closer to the scalp, which can improve the accuracy and comfort of brain activity mapping.24678

What data supports the effectiveness of the treatment OPM MEG?

Research shows that OPM MEG systems can capture high-quality brain signals with improved sensitivity and spatial resolution compared to traditional methods. Studies have demonstrated that OPM MEG can accurately pinpoint brain activity with minimal spatial discrepancy, even in challenging environments, suggesting its potential effectiveness in brain mapping.34789

Who Is on the Research Team?

AC

Allison C Nugent, Ph.D.

Principal Investigator

National Institute of Mental Health (NIMH)

Are You a Good Fit for This Trial?

Healthy adults aged 18-65 who've had an MRI scan under a specific protocol can join this study. They should be in good health, able to follow the study's procedures, and available for its duration. People with metal in their body that affects MEG recordings cannot participate.

Inclusion Criteria

Provision of signed and dated informed consent form
Stated willingness to comply with all study procedures and availability for the duration of the study
In good general health as evaluated according to protocol 17-M-0181
See 1 more

Exclusion Criteria

Participants excluded from 17-M-0181 will be excluded from this protocol
Metal in the body which would cause artifacts on MEG recordings

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 day

Testing

Participants undergo testing with both the traditional MEG instrument and the OPM array, including various sensory tasks and nerve stimulation.

1 day
1 visit (in-person)

Optional Follow-up

Additional optional scans may be offered to participants for further testing and data collection.

up to 1 year

What Are the Treatments Tested in This Trial?

Interventions

  • OPM MEG
  • SQUID MEG
Trial Overview The trial is testing a new brain activity sensor called OPM against the traditional SQUID MEG. Participants will wear special equipment on their head and complete tasks involving touch, sight, sound, or language stimuli while magnetic fields are measured.
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: OPM Array studiesExperimental Treatment2 Interventions
Testing of a final 49-61 channel OPM MEG system and any interim arrays

Find a Clinic Near You

Who Is Running the Clinical Trial?

National Institute of Mental Health (NIMH)

Lead Sponsor

Trials
3,007
Recruited
2,852,000+

Published Research Related to This Trial

The new artifact reduction method called frequency specific signal space classification (FSSSC) significantly improves the signal-to-noise ratio in magnetoencephalography (MEG) recordings using optically pumped magnetometers (OPMs), enhancing the accuracy of source localization.
FSSSC effectively removes artifacts from MEG recordings, allowing for clearer detection of auditory evoked magnetic fields in human subjects, which is crucial for advancing brain research and making OPMs a viable alternative to traditional MEG systems.
Spatial and Frequency Specific Artifact Reduction in Optically Pumped Magnetometer Recordings.Xiang, J., Tong, H., Jiang, Y., et al.[2023]
The HEDscan, a 128-sensor optically-pumped magnetometer (OPM) MEG system, demonstrates high performance in capturing brain signals, validated through studies with six healthy adults during auditory tests.
Results from the OPM-MEG system align well with conventional cryogenic MEG, indicating that this new technology can effectively measure brain activity with high signal amplitudes and reliability.
An integrated full-head OPM-MEG system based on 128 zero-field sensors.Alem, O., Hughes, KJ., Buard, I., et al.[2023]
The optically-pumped magnetometer (OPM) MEG system can effectively detect alpha rhythm changes in response to light stimulation, demonstrating comparable sensitivity to traditional SQUID-based MEG systems.
This new OPM-MEG technology allows sensors to be placed much closer to the scalp (less than 1 cm), improving detection efficiency and potentially offering a more practical alternative to conventional MEG systems that rely on liquid helium.
Detection and analysis of MEG signals in occipital region with double-channel OPM sensors.Zhang, X., Chen, CQ., Zhang, MK., et al.[2021]

Citations

Spatial and Frequency Specific Artifact Reduction in Optically Pumped Magnetometer Recordings. [2023]
An integrated full-head OPM-MEG system based on 128 zero-field sensors. [2023]
Detection and analysis of MEG signals in occipital region with double-channel OPM sensors. [2021]
On the Potential of a New Generation of Magnetometers for MEG: A Beamformer Simulation Study. [2022]
Using OPM-MEG in contrasting magnetic environments. [2022]
Precision magnetic field modelling and control for wearable magnetoencephalography. [2022]
Reducing crosstalk in optically-pumped magnetometer arrays. [2023]
A high-performance compact magnetic shield for optically pumped magnetometer-based magnetoencephalography. [2019]
Detection of the 40 Hz auditory steady-state response with optically pumped magnetometers. [2023]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of ServiceยทPrivacy PolicyยทCookiesยทSecurity