Diagnostic Imaging Techniques for Shoulder Osteoarthritis
(UESOA Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment Low-dose CT, Motion Analysis, T1Rho MRI for shoulder osteoarthritis?
Is it safe to use diagnostic imaging techniques like Low-dose CT and T1Rho MRI for shoulder osteoarthritis?
How is the imaging treatment for shoulder osteoarthritis different from other treatments?
This treatment uses advanced imaging techniques like 3D MRI and ultra-low-dose CT scans to create detailed models of the shoulder, which can help in diagnosing and planning treatment for osteoarthritis. Unlike traditional methods, these techniques offer a non-invasive way to visualize the joint in three dimensions, potentially improving accuracy in diagnosis and surgical planning.12379
What is the purpose of this trial?
Osteoarthritis (OA) is a progressive disease resulting from the degradation of synovial joint articular cartilage over time.The hallmark symptom is diffuse aching and progressive pain made worse with activity. Loss of range of motion and compromised function inevitably follow. This degenerative disease can affect the shoulder joint. When symptoms become refractory to conservative treatment such as anti-inflammatory medication, steroid injections, activity modification or physical therapy; surgery (total or reverse shoulder arthroplasty) may be considered.Idiopathic shoulder OA is typically characterized by posterior subluxation of the humeral head upon the glenoid and posterior bone loss. An imbalance in the application of forces applied to the proximal humerus by the posterior and anterior rotator cuff muscles has been postulated to be the leading cause of idiopathic shoulder OA. However, there is only preliminary evidence to support this theory and the etiology of this pattern of deformity is unknown. The theory the posterior humeral head subluxation is a precursor to OA is only supported by very low-level evidence and no longitudinal studies have been conducted. As a result, the cause and natural history of shoulder OA remains unknown.Research into this area is urgently needed to generate knowledge that will inform future treatments aimed at modifying and slowing the progression of shoulder OA and to reduce the need for shoulder replacement therapy.The aim of this project is to develop an understanding of the pathophysiology of shoulder OA.
Research Team
Peter Lapner, MD
Principal Investigator
The Ottawa Hospital Research Institute
Eligibility Criteria
This trial is for adults under 60 with shoulder osteoarthritis, specifically those showing more than 55% posterior humeral head subluxation on imaging. It's not suitable for individuals over 60, those with labral or rotator cuff issues, pre-existing joint deformities beyond grade I, neurological disorders of the upper limb, history of shoulder instability or trauma including fractures.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Initial assessments including T1Rho MRI, qCT, and functional/motion analysis
Ongoing Assessment
Participants undergo T1Rho MRI, qCT, and motion analysis at year 2 and year 4
Finite Element Model Validation
Finite element model validation performed in years 2 and 3
Follow-up
Participants are monitored for safety and effectiveness after assessments
Treatment Details
Interventions
- Low-dose CT
- Motion Analysis
- T1Rho MRI
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ottawa Hospital Research Institute
Lead Sponsor
University of Ottawa
Collaborator