Diagnostic Imaging Techniques for Shoulder Osteoarthritis
(UESOA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to better understand shoulder osteoarthritis (OA), focusing on its causes and progression. Researchers use advanced imaging techniques like low-dose CT (a type of computed tomography scan with reduced radiation) and T1Rho MRI (a specialized magnetic resonance imaging technique) to study shoulder joints. The goal is to find ways to slow OA and reduce the need for shoulder surgeries. Participants should have a specific shoulder condition called posterior subluxation, where the upper arm bone shifts back more than usual, and either show early signs of OA or none at all. This trial may suit adults under 60 who haven't experienced significant shoulder injuries or conditions. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to new insights and treatments for shoulder OA.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that these diagnostic imaging techniques are safe for studying shoulder osteoarthritis?
Research has shown that the treatments in this study are safe. Studies have found that low-dose CT scans use much less radiation than standard CT scans, making them generally easy to handle with few side effects. They are designed to reduce radiation exposure while still providing clear images.
Motion analysis, another component of this study, is non-invasive. It tracks joint movement and muscle function during activities. This method poses no known safety issues, as it only observes and records motion.
Lastly, T1Rho MRI is a special imaging technique that provides detailed pictures of cartilage. It has been used safely in both healthy individuals and those with osteoarthritis. This method is non-invasive and does not involve radiation.
Overall, these treatments are considered safe with minimal risk to participants.12345Why are researchers excited about this trial?
Researchers are excited about these diagnostic imaging techniques for shoulder osteoarthritis because they offer new ways to detect and understand the condition early. The low-dose CT provides detailed images with less radiation exposure, making it safer compared to traditional CT scans. Motion analysis captures real-time movement, helping to assess how shoulder function is affected, while T1Rho MRI reveals subtle changes in cartilage health that aren't visible in standard MRIs. Together, these methods could lead to earlier and more precise diagnosis, potentially improving treatment outcomes for patients.
What evidence suggests that these diagnostic imaging techniques are effective for understanding shoulder osteoarthritis?
This trial will compare different diagnostic imaging techniques for shoulder osteoarthritis. Research has shown that low-dose CT scans effectively provide detailed images for diagnosing shoulder problems and planning surgeries, making them useful for understanding shoulder osteoarthritis (OA). Motion analysis, using advanced technology, promises to improve diagnostic accuracy and consistency in assessing shoulder issues. T1Rho MRI helps detect early cartilage wear and tear, which is important for tracking the progression of shoulder OA. While primarily diagnostic, these tools are crucial for developing future treatments by offering clear insights into how shoulder OA develops and progresses.56789
Who Is on the Research Team?
Peter Lapner, MD
Principal Investigator
The Ottawa Hospital Research Institute
Are You a Good Fit for This Trial?
This trial is for adults under 60 with shoulder osteoarthritis, specifically those showing more than 55% posterior humeral head subluxation on imaging. It's not suitable for individuals over 60, those with labral or rotator cuff issues, pre-existing joint deformities beyond grade I, neurological disorders of the upper limb, history of shoulder instability or trauma including fractures.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Initial assessments including T1Rho MRI, qCT, and functional/motion analysis
Ongoing Assessment
Participants undergo T1Rho MRI, qCT, and motion analysis at year 2 and year 4
Finite Element Model Validation
Finite element model validation performed in years 2 and 3
Follow-up
Participants are monitored for safety and effectiveness after assessments
What Are the Treatments Tested in This Trial?
Interventions
- Low-dose CT
- Motion Analysis
- T1Rho MRI
Trial Overview
The study aims to understand the causes and progression of shoulder osteoarthritis by using low-dose CT scans, T1Rho MRI imaging techniques and motion analysis to observe changes in the joint over time.
How Is the Trial Designed?
Those who have posterior subluxation of the humeral head and show early signs of degeneration in their shoulder.
Those who have posterior subluxation of the humeral head and show no signs of degeneration.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ottawa Hospital Research Institute
Lead Sponsor
University of Ottawa
Collaborator
Citations
The clinical performance of ultra-low-dose shoulder CT scans
The ultra-low-dose protocol functioned well in the diagnosis of fracture pattern of an injured shoulder. The ultra-low-dose protocol scored more ...
Unravelling the Etiology of Shoulder Osteoarthritis
A low-dose, or quantitative (q) CT scan will be performed on the shoulder. This CT scan will be done to assess the bony structure of the shoulder, as well as ...
3.
insightsimaging.springeropen.com
insightsimaging.springeropen.com/articles/10.1186/s13244-025-02119-xDiagnostic performance of dual-energy CT for ...
This retrospective study evaluated patients diagnosed with rotator cuff disease who underwent third-generation dual-source DECT and 3.0-T MRI ...
The clinical performance of ultra-low-dose shoulder CT scans
An ultra-low-dose protocol is adequate for the diagnosis of either displaced or non-displaced fractures of the shoulder joint even though minor flaws of images ...
Diagnostic Imaging Techniques for Shoulder Osteoarthritis ...
Research shows that low-dose CT scans can effectively provide detailed images for diagnosing shoulder issues and planning surgeries, while MRI techniques like ...
Diagnostic accuracy of ultra-low-dose CT compared ...
The ED for the ULD-CT protocol was significantly lower (shoulder, knee, ankle, wrist: 23.21 ± 2.24 μSv, 2.10 ± 0.25 μSv, 1.02 ± 0.11, 0.29 ± 0. ...
Low-dose Radiation Therapy (LDRT) in Managing ...
Additionally, LDRT is generally well-tolerated and carries a lower risk of adverse effects compared to higher-dose radiation therapies used in ...
Geometric accuracy of low-dose CT scans for use in ...
All low-dose protocols resulted in a >70 % reduction in the effective dose. Lower dose scans resulted in higher geometric errors; however, error magnitudes were ...
The Use of Low-Dose Radiation Therapy in Osteoarthritis
LDRT has been shown to be a cost-effective, noninvasive treatment with minimal side effects. Further investigation into the potential role in ...
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