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Inhaled Anesthetic

Nitrous Oxide for OCD

Phase 2
Led By Peter J van Roessel, MD, PhD
Research Sponsored by Stanford University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Primary diagnosis of OCD
Sufficient severity of OCD symptoms
Must not have
Be younger than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up1 week
Awards & highlights

Study Summary

This trial looks at whether nitrous oxide, a gas used during surgery to keep people pain-free and relaxed, can help people with OCD who haven't responded to other treatments.

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have been diagnosed with Obsessive-Compulsive Disorder (OCD).
You have severe symptoms of OCD.
You are able to take a break from your current treatment.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Experimental: Nitrous OxideExperimental Treatment1 Intervention
OCD participants in this arm will receive 50%oxygen/50% nitrous oxide admixture for 60 minutes.
Group II: Control: NitrogenPlacebo Group1 Intervention
OCD participants in this arm will receive 50%oxygen/50% nitrogen admixture for 60 minutes.
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitrous Oxide
Completed Phase 4

Find a Location

Who is running the clinical trial?

Stanford UniversityLead Sponsor
2,324 Previous Clinical Trials
17,287,699 Total Patients Enrolled
13 Trials studying Obsessive-Compulsive Disorder
1,371 Patients Enrolled for Obsessive-Compulsive Disorder
Brain & Behavior Research FoundationOTHER
61 Previous Clinical Trials
2,768 Total Patients Enrolled
1 Trials studying Obsessive-Compulsive Disorder
148 Patients Enrolled for Obsessive-Compulsive Disorder
Peter J van Roessel, MD, PhD5.02 ReviewsPrincipal Investigator - Stanford Univeristy
Stanford University
1 Previous Clinical Trials
16 Total Patients Enrolled
1 Trials studying Obsessive-Compulsive Disorder
16 Patients Enrolled for Obsessive-Compulsive Disorder

Media Library

Nitrous Oxide (Inhaled Anesthetic) Clinical Trial Eligibility Overview. Trial Name: NCT03826693 — Phase 2
Obsessive-Compulsive Disorder Research Study Groups: Experimental: Nitrous Oxide, Control: Nitrogen
Obsessive-Compulsive Disorder Clinical Trial 2023: Nitrous Oxide Highlights & Side Effects. Trial Name: NCT03826693 — Phase 2
Nitrous Oxide (Inhaled Anesthetic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03826693 — Phase 2
Obsessive-Compulsive Disorder Patient Testimony for trial: Trial Name: NCT03826693 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this study seek elderly participants?

"The aim of this research is to enroll patients that are young adults between 18 and 65 years old."

Answered by AI

What governmental regulations have been put in place for Nitrous Oxide?

"There is some clinical data suggesting that Nitrous Oxide is safe, but none attesting to its efficacy. Consequently, it received a score of 2."

Answered by AI

To what effect is Nitrous Oxide typically employed?

"Nitrous oxide can be used for pain management during procedures such as benign skin lesion removal and respiratory challenge tests."

Answered by AI

Would I be able to help test this new medication by enrolling in the clinical trial?

"Eligible patients for this trial must be 18-65 years old, suffering from OCD with moderate to high symptom severity, and able to go without treatment for a set period of time."

Answered by AI

Are there any more patients needed to participate in this clinical trial?

"Yes, this is an ongoing clinical trial that was originally posted on April 17th, 2021. The study was last updated on September 23rd, 2022 and is looking for 45 participants from 1 location."

Answered by AI

What is the projected total enrollment for this clinical trial?

"That is correct. The clinical trial in question, as indicated by information on clinicaltrials.gov, is still ongoing and looking for 45 individuals from 1 site."

Answered by AI

What are some similar studies to the one involving Nitrous Oxide?

"Currently, there are 18 clinical studies underway that involve Nitrous Oxide. 2 of those trials have progressed to Phase 3 testing. The majority of the locations where these tests are being conducted are in Stanford, California; however, 20 different centres across the USA are running active trials."

Answered by AI

Who else is applying?

What state do they live in?
What site did they apply to?
Stanford University
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?

Why did patients apply to this trial?

I still suffer from usually terrible and sometimes disabling OCD. I am interested in furthering availability of treatments for OCD.
PatientReceived no prior treatments
~10 spots leftby Sep 2024