Music Video Game for Schizophrenia

Recruiting at 1 trial location

Overseen By Joshua J Chiappelli, MD

Age: < 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Maryland, Baltimore

Compensation: Varies

Number of Visits: Unknown

36 Participants Needed

Trial Summary

What is the purpose of this trial?

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Eligibility Criteria

This trial is for individuals aged 15-45 who have been diagnosed with schizophrenia or related disorders and can give informed consent. It's not suitable for those with hand-use limitations, MRI contraindications like metal implants or claustrophobia, or a recent substance use disorder.

Inclusion Criteria

I am between 15 and 45 years old.

Able to provide informed consent

I have been diagnosed with a schizophrenia spectrum disorder.

Exclusion Criteria

I have a condition like arthritis that limits my hand use.

Contraindications to MRI (metal implants, claustrophobia)

Active or recent (within 6 months) substance use disorder other than nicotine

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Active Training

Participants undergo training sessions involving playing the video game 'Guitar Hero' to study white matter structure changes

3 weeks

Observation Training

Participants in the placebo group do not receive active training but are observed for changes in white matter microstructure

3 weeks

Follow-up

Participants are monitored for safety and effectiveness after training

4 weeks

Treatment Details

Interventions

• Music video game

Trial Overview The study investigates if playing a music video game can improve the brain's white matter structure in people with schizophrenia. This could potentially enhance their cognitive functions, particularly processing speed by simulating playing an instrument.

Participant Groups

Group I: Active training Active Control 1 Intervention

Training sessions involving playing the video game 'Guitar Hero'

Group II: Observation training Placebo Group 1 Intervention

Who Is Running the Clinical Trial?

University of Maryland, Baltimore

Lead Sponsor

Trials

729

Recruited

540,000+