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Exposure Therapy for Anxiety Disorders

Boston University, Boston, MA
Targeting 6 different conditionsExposure-Based TherapyN/ARecruitingLed by Jasper Smits, Ph.D.Research Sponsored by University of Texas at Austin

Study Summary

This trial is designed to see if a new biomarker can help predict which patients will respond to exposure-based therapy for anxiety, OCD and stress-related disorders.

Eligible Conditions
  • Agoraphobia
  • Obsessive-Compulsive Disorder
  • Panic Disorder
  • Post-Traumatic Stress Disorder
  • Social Anxiety Disorder
  • Generalized Anxiety Disorder

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You have been diagnosed with a mental health condition such as panic disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, or post-traumatic stress disorder. The diagnosis was made using a specific interview called the Structured Clinical Interview for the DSM-5 (SCID-5).


Screening ~ 1 day
Treatment ~ 12 weeks
Follow Up ~3 months
This trial's timeline: 1 day for screening, 12 weeks for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Non-response to exposure-based therapy
Secondary outcome measures
Clinical Global Impression - Severity of Illness (CGI-S)
Dimensional Obsessive-Compulsive Scale (DOCS)
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Open Exposure-Based Therapy (EBT)Experimental Treatment1 Intervention
All participants will receive a well-established psychological treatment.

Find a Location

Who is running the clinical trial?

University of Texas at AustinLead Sponsor
341 Previous Clinical Trials
78,444 Total Patients Enrolled
2 Trials studying Obsessive-Compulsive Disorder
161 Patients Enrolled for Obsessive-Compulsive Disorder
Boston UniversityOTHER
446 Previous Clinical Trials
9,911,631 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,717 Previous Clinical Trials
2,422,925 Total Patients Enrolled
65 Trials studying Obsessive-Compulsive Disorder
13,381 Patients Enrolled for Obsessive-Compulsive Disorder

Media Library

Exposure-Based Therapy (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05467683 — N/A
Obsessive-Compulsive Disorder Research Study Groups: Open Exposure-Based Therapy (EBT)
Obsessive-Compulsive Disorder Clinical Trial 2023: Exposure-Based Therapy Highlights & Side Effects. Trial Name: NCT05467683 — N/A
Exposure-Based Therapy (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05467683 — N/A
Obsessive-Compulsive Disorder Patient Testimony for trial: Trial Name: NCT05467683 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I eligible to participate in this experiment?

"This medical study requires 600 individuals with Obsessive-Compulsive Disorder (OCD) aged between 18 and 70 to participate. Eligibility is further restricted by a DSM-5 diagnosis, an OASIS score of 8 or higher, proficiency in English, as well as the willingness and capacity for informed consent."

Answered by AI

How many individuals are enrolled in this experiment?

"Affirmative. According to clinicaltrials.gov, this experiment is recruiting individuals as of November 2nd 2022 and requires 600 participants from two sites. It was first posted on the same date and has been periodically renewed since then."

Answered by AI

Is this trial currently open to new enrollees?

"According to clinicaltrials.gov, this medical trial is presently accepting participants as of its most recent edit on November 2nd 2022. The experiment was initially posted the same day for recruitment purposes."

Answered by AI

Does this investigation seek individuals aged 25 and up?

"The current study accepts patients aged 18 to 70, with 377 trials targeting those under the age of majority and 1107 for individuals over 65."

Answered by AI

Who else is applying?

What state do they live in?
What site did they apply to?
Boston University
The University of Texas at Austin
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?

Why did patients apply to this trial?

I need advice on copying with these disorders! I have tried multiple medications and ERP and am looking for alternatives.
PatientReceived no prior treatments
I’ve found it very difficult to find a decent provider who can treat me effectively. Many are determined to prescribe medications that they prefer, while ignoring my experiences with medications and my general health and wellbeing.
PatientReceived 1 prior treatment

What questions have other patients asked about this trial?

Do I need to go somewhere to be screened? How long is the study and how much does it pay?
PatientReceived no prior treatments

How responsive is this trial?

Typically responds via
Phone Call
Most responsive sites:
  1. The University of Texas at Austin: < 48 hours
Average response time
  • < 2 Days
~400 spots leftby Dec 2026