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Exposure-Based Therapy for Anxiety Disorders
Verified Trial
N/A
Recruiting
Led By Michael Otto, Ph.D.
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Are you able to attend 12 weekly in-person sessions at the University of Texas at Austin?
Do you have a diagnosis of panic disorder (with or without an agoraphobia diagnosis), social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, or post-traumatic stress disorder?
Must not have
Do you have any of the following: cardiac arrhythmia, cardiac failure, asthma, lung fibrosis, high blood pressure, epilepsy, or stroke?
Are you currently pregnant or lactating?
Timeline
Screening 1 day
Treatment 12 weeks
Follow Up 3 months
Awards & highlights
No Placebo-Only Group
Summary
This trial is designed to see if a new biomarker can help predict which patients will respond to exposure-based therapy for anxiety, OCD and stress-related disorders.
Who is the study for?
Adults aged 18-70 with anxiety, OCD, or PTSD who can consent and follow the study plan. They must speak English and have a certain level of anxiety. Those stable on meds for at least 8 weeks may join; however, people with bipolar/psychotic disorders, recent substance/eating disorders, serious cognitive issues, or conditions that make CO2 challenges unsafe cannot participate.
What is being tested?
The trial is testing if a simple CO2 challenge can predict who won't respond well to exposure-based therapy for various anxiety-related conditions. It aims to help clinicians decide whether this type of therapy should be started.
What are the potential side effects?
While not explicitly listed in the provided information, potential side effects from the CO2 challenge could include shortness of breath, dizziness, increased heart rate or panic due to the sensation of suffocation which might trigger anxiety symptoms.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowExclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Timeline
Screening ~ 1 day2 visits
Treatment ~ 12 weeks12 visits
Follow Up ~ 3 months0 visits
Screening ~ 1 day
Treatment ~ 12 weeks
Follow Up ~3 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Non-response to exposure-based therapy
Secondary study objectives
Clinical Global Impression - Severity of Illness (CGI-S)
Dimensional Obsessive-Compulsive Scale (DOCS)
GAD-7
+4 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
1Treatment groups
Experimental Treatment
Group I: Open Exposure-Based Therapy (EBT)Experimental Treatment1 Intervention
All participants will receive a well-established psychological treatment.
Find a Location
Who is running the clinical trial?
University of Texas at AustinLead Sponsor
374 Previous Clinical Trials
85,575 Total Patients Enrolled
2 Trials studying Obsessive-Compulsive Disorder
161 Patients Enrolled for Obsessive-Compulsive Disorder
Boston UniversityOTHER
470 Previous Clinical Trials
9,987,148 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,910 Previous Clinical Trials
2,738,575 Total Patients Enrolled
67 Trials studying Obsessive-Compulsive Disorder
13,483 Patients Enrolled for Obsessive-Compulsive Disorder
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I do not have heart issues, asthma, lung problems, high blood pressure, epilepsy, or a history of stroke.I am between 18 and 70 years old.I don't have conditions like heart issues, asthma, high BP, epilepsy, or stroke that make CO2 inhalation risky.I have been diagnosed with an anxiety disorder or PTSD.
Research Study Groups:
This trial has the following groups:- Group 1: Open Exposure-Based Therapy (EBT)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 1 Weeks to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 12 Weeks
- Follow Ups: You may be asked to continue sharing information regarding the trial for 3 Months after you stop receiving the treatment.
Obsessive-Compulsive Disorder Patient Testimony for trial: Trial Name: NCT05467683 — N/A
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