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Exposure-Based Therapy for Anxiety Disorders
N/A
Recruiting
Led By Jasper Smits, Ph.D.
Research Sponsored by University of Texas at Austin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
A primary DSM-5 diagnosis of panic disorder (with or without an agoraphobia diagnosis), social anxiety disorder, generalized anxiety disorder, obsessive-compulsive disorder, or post-traumatic stress disorder as assessed by the Structured Clinical Interview for the DSM-5 (SCID-5)
Ages 18 to 70
Timeline
Screening 1 day
Treatment 12 weeks
Follow Up 3 months
Awards & highlights
Study Summary
This trial is designed to see if a new biomarker can help predict which patients will respond to exposure-based therapy for anxiety, OCD and stress-related disorders.
Who is the study for?
Adults aged 18-70 with anxiety, OCD, or PTSD who can consent and follow the study plan. They must speak English and have a certain level of anxiety. Those stable on meds for at least 8 weeks may join; however, people with bipolar/psychotic disorders, recent substance/eating disorders, serious cognitive issues, or conditions that make CO2 challenges unsafe cannot participate.Check my eligibility
What is being tested?
The trial is testing if a simple CO2 challenge can predict who won't respond well to exposure-based therapy for various anxiety-related conditions. It aims to help clinicians decide whether this type of therapy should be started.See study design
What are the potential side effects?
While not explicitly listed in the provided information, potential side effects from the CO2 challenge could include shortness of breath, dizziness, increased heart rate or panic due to the sensation of suffocation which might trigger anxiety symptoms.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have been diagnosed with an anxiety disorder or PTSD.
Select...
I am between 18 and 70 years old.
Timeline
Screening ~ 1 day2 visits
Treatment ~ 12 weeks12 visits
Follow Up ~ 3 months0 visits
Screening ~ 1 day
Treatment ~ 12 weeks
Follow Up ~3 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Non-response to exposure-based therapy
Secondary outcome measures
Clinical Global Impression - Severity of Illness (CGI-S)
Dimensional Obsessive-Compulsive Scale (DOCS)
GAD-7
+4 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Open Exposure-Based Therapy (EBT)Experimental Treatment1 Intervention
All participants will receive a well-established psychological treatment.
Find a Location
Who is running the clinical trial?
University of Texas at AustinLead Sponsor
353 Previous Clinical Trials
80,644 Total Patients Enrolled
2 Trials studying Obsessive-Compulsive Disorder
161 Patients Enrolled for Obsessive-Compulsive Disorder
Boston UniversityOTHER
454 Previous Clinical Trials
9,940,970 Total Patients Enrolled
National Institute of Mental Health (NIMH)NIH
2,785 Previous Clinical Trials
2,689,156 Total Patients Enrolled
65 Trials studying Obsessive-Compulsive Disorder
13,381 Patients Enrolled for Obsessive-Compulsive Disorder
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You have an anxiety score of 8 or higher on a test called the OASIS.I do not have heart issues, asthma, lung problems, high blood pressure, epilepsy, or a history of stroke.I am between 18 and 70 years old.I don't have conditions like heart issues, asthma, high BP, epilepsy, or stroke that make CO2 inhalation risky.You are pregnant or currently breastfeeding.I started my medication within the last 8 weeks and it's stable.You have had thoughts of hurting or killing yourself in the past 6 months and may have taken steps towards doing so.I am currently receiving psychotherapy for my main mental health condition.I have been diagnosed with an anxiety disorder or PTSD.You have a history of bipolar disorder, psychotic disorders, substance abuse, or an eating disorder within the past 6 months. You also have significant problems with memory, thinking, or learning.
Research Study Groups:
This trial has the following groups:- Group 1: Open Exposure-Based Therapy (EBT)
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 1 Weeks to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 12 Weeks
- Follow Ups: You may be asked to continue sharing information regarding the trial for 3 Months after you stop receiving the treatment.
Obsessive-Compulsive Disorder Patient Testimony for trial: Trial Name: NCT05467683 — N/A
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Am I eligible to participate in this experiment?
"This medical study requires 600 individuals with Obsessive-Compulsive Disorder (OCD) aged between 18 and 70 to participate. Eligibility is further restricted by a DSM-5 diagnosis, an OASIS score of 8 or higher, proficiency in English, as well as the willingness and capacity for informed consent."
Answered by AI
How many individuals are enrolled in this experiment?
"Affirmative. According to clinicaltrials.gov, this experiment is recruiting individuals as of November 2nd 2022 and requires 600 participants from two sites. It was first posted on the same date and has been periodically renewed since then."
Answered by AI
Is this trial currently open to new enrollees?
"According to clinicaltrials.gov, this medical trial is presently accepting participants as of its most recent edit on November 2nd 2022. The experiment was initially posted the same day for recruitment purposes."
Answered by AI
Does this investigation seek individuals aged 25 and up?
"The current study accepts patients aged 18 to 70, with 377 trials targeting those under the age of majority and 1107 for individuals over 65."
Answered by AI
Who else is applying?
What state do they live in?
Texas
What site did they apply to?
Boston University
The University of Texas at Austin
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
0
3+
Why did patients apply to this trial?
I need advice on copying with these disorders! I need the money. And I feel anxious. All the time.
PatientReceived no prior treatments
I’ve tried a couple of drugs, but I don’t think they work. I have tried multiple medications and ERP and am looking for alternatives.
PatientReceived no prior treatments
What questions have other patients asked about this trial?
Do I need to go somewhere to be screened? How long is the study and how much does it pay?
PatientReceived no prior treatments
How responsive is this trial?
Typically responds via
Phone Call
Most responsive sites:
- The University of Texas at Austin: < 48 hours
Average response time
- < 2 Days
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