Dietary Biomarkers Development for Healthy Adults
(P2-SDBDC Trial)
Trial Summary
What is the purpose of this trial?
The Seattle Dietary Biomarker Development Center (S-DBDC) aims to advance the science of measuring dietary intake by identification and validation of dietary biomarkers that improve upon self-reported diet. To accomplish this mission, the Seattle DBDC will carry out controlled feeding studies in healthy human volunteers. Metabolomics assays will be conducted on blood and urine specimens collected during the feeding studies for biomarker identification. Stool samples will be collected and archived.
Research Team
Marian L. Neuhouser
Principal Investigator
Fred Hutchinson Cancer Center
Johanna W. Lampe, PhD, RD
Principal Investigator
Fred Hutchinson Cancer Center
Eligibility Criteria
This trial is for healthy adults who can participate in controlled feeding studies. Specific eligibility criteria are not provided, but typically participants must be willing to follow dietary guidelines and provide biological samples.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Controlled Feeding Period 1
Participants undergo a 2-day run-in of controlled feeding followed by a 7-day feeding period on either a higher or lower HEI-2020 diet
Washout
Participants undergo a washout period between feeding periods
Controlled Feeding Period 2
Participants undergo a second 2-day run-in of controlled feeding followed by a 7-day feeding period on the alternate HEI-2020 diet
Follow-up
Participants are monitored for biomarker identification and validation after the feeding periods
Treatment Details
Interventions
- Higher HEI-2020 diet followed by lower HEI-2020 diet
- Lower HEI-2020 diet followed by higher HEI-2020 diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Marian Neuhouser
Lead Sponsor
University of Nebraska
Collaborator
United States Department of Agriculture - National Institute of Food and Agriculture (USDA-NIFA)
Collaborator
University of Washington
Collaborator
Duke University
Collaborator