Study Summary
This trial will test whether long-acting metformin can prevent or delay cognitive decline in people with early and late Alzheimer's disease.
- Mild Cognitive Impairment
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 8 Secondary · Reporting Duration: 24 months
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
2 Treatment Groups
metformin users
1 of 2
metformin non-users
1 of 2
Experimental Treatment
Non-Treatment Group
370 Total Participants · 2 Treatment Groups
Primary Treatment: metformin users · Has Placebo Group · Phase 2 & 3
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 55 - 90 · All Participants · 0 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| New York | 22.4% |
| Illinois | 17.2% |
| Washington | 13.8% |
| Other | 46.6% |
How old are they?
| 18 - 65 | 50.0% |
| 65+ | 50.0% |
What site did they apply to?
| Rush University Medical Center | 20.8% |
| Columbia University Medical Center | 14.6% |
| University of Washington | 16.7% |
| Other | 47.9% |
What portion of applicants met pre-screening criteria?
| Met criteria | 38.6% |
| Did not meet criteria | 61.4% |
Why did patients apply to this trial?
- "I'm concerned with my memory."
- "i DONT QUALIFY FOR MANY STUDIES, DUE TO AGE."
- "Does not qualify for other studies.He is 88."
- "Just been told about my condition about year ago"
- "Ive noticed an increas in memory loss over the past"
How many prior treatments have patients received?
| 0 | 81.5% |
| 1 | 18.5% |
What questions have other patients asked about this trial?
- "Are you paid for this study?"
- "How long do screening test take ?"
- "How long is the study and how many days?"
How responsive is this trial?
Typically responds via
| Phone Call | 88.2% |
| 11.8% | |
Average response time
- < 2 Days
Most responsive sites:
- Wake Forest University Health Sciences: < 24 hours
- Georgetown University: < 24 hours
- University of Washington: < 48 hours
Frequently Asked Questions
Will this clinical trial consider applicants who are over 18 years old?
"The age limit for this study is 55-90 years old." - Anonymous Online Contributor
What is the most common ailment that metformin is used to address?
"Exercise is most commonly treated with metformin. Metformin is also effective at treating other conditions including type 1 diabetes mellitus, diabetic ketoacidosis, and polycystic ovary syndrome." - Anonymous Online Contributor
Are people still able to sign up for this experiment?
"The trial, which is currently looking for participants, was originally posted on March 22nd 2021. The listing was updated on October 31st of this year." - Anonymous Online Contributor
Is there precedent for this proposed metformin study?
"There are currently 45 Phase 3 trials and 180 active studies investigating the use of metformin. Many of these medical investigations are based in Pittsburgh, but there are 1952 locations across the globe conducting similar research." - Anonymous Online Contributor
How many study participants are needed for this clinical trial?
"In order for this trial to be completed, 370 eligible individuals must enroll. Those who wish to participate can do so at Columbia University Medical Center or New York University Langone Medical Center." - Anonymous Online Contributor
Is this a widespread or localized study?
"To limit the inconvenience of travel, please enroll at the location nearest to you from the 10 sites currently recruiting patients. These locations include New York, Chicago and Boston among others." - Anonymous Online Contributor
Could I potentially qualify to participate in this research?
"Up to 370 individuals with mci will be enrolled in this study. These participants must be between 55 and 90 years old and meet the following requirements: Abnormal memory function as documented by a score within the education-adjusted ranges on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale-Revised., Clinical Dementia Rating 0.5. The memory box score must be at least 0.5., General cognition and functional performance that is preserved enough such that a diagnosis of Alzheimer's disease cannot be made by the site physician at the time of screening visit" - Anonymous Online Contributor