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MAP (MAP Trial)
MAP Trial Summary
This trial will test whether long-acting metformin can prevent or delay cognitive decline in people with early and late Alzheimer's disease.
MAP Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowMAP Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.MAP Trial Design
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Who is running the clinical trial?
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- You cannot participate in the study if you have a low body mass index, kidney disease with an estimated glomerular filtration rate of less than 45 mL/min, liver disease other than non-fatty liver disease or class III or IV congestive heart failure, moderate to severe depression, dementia, or a history of intolerance to metformin. You also cannot participate if you have had a cerebrovascular accident with residual neurological deficits, neurologic diseases associated with neurological deficits, active cancer or a history of cancer in the last two years (except for certain types of skin cancer), uncontrolled hypertension, or are planning to move to another city or state within the next 24 months. Additionally, you cannot participate if you have a known history of diabetes or if it is discovered during screening using HbA1c criteria. You also cannot participate if you are taking certain medications or treatments, such as aducanumab or amyloid modifying treatments for Alzheimer's disease, or if you are pregnant or planning to become pregnant. Finally, you cannot participate if you are unable to undergo phlebotomy.I have never been diagnosed with Alzheimer's disease.My education level is between 8-15 years.My education level is between 0-7 years and my score is between 3-6.I have been diagnosed with cancer.I have someone close who can discuss my daily activities.You must have some memory problems, as shown by a score of at least 0.5 on a memory test.Your memory and ability to do daily activities are not severely affected by Alzheimer’s disease or other cognitive impairments, as determined by the doctor during the screening visit.I have never taken metformin.I have 16+ years of education and scored ≤ 8.The person has an abnormal memory function that has been documented by scoring within the education adjusted ranges on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale-Revised.
- Group 1: metformin non-users
- Group 2: metformin users
- Screening: It may take up to 2 Months to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 24 Months
- Follow Ups: You may be asked to continue sharing information regarding the trial for 0 Months after you stop receiving the treatment.
Frequently Asked Questions
Will this clinical trial consider applicants who are over 18 years old?
"The age limit for this study is 55-90 years old."
What is the most common ailment that metformin is used to address?
"Exercise is most commonly treated with metformin. Metformin is also effective at treating other conditions including type 1 diabetes mellitus, diabetic ketoacidosis, and polycystic ovary syndrome."
Are people still able to sign up for this experiment?
"The trial, which is currently looking for participants, was originally posted on March 22nd 2021. The listing was updated on October 31st of this year."
Is there precedent for this proposed metformin study?
"There are currently 45 Phase 3 trials and 180 active studies investigating the use of metformin. Many of these medical investigations are based in Pittsburgh, but there are 1952 locations across the globe conducting similar research."
How many study participants are needed for this clinical trial?
"In order for this trial to be completed, 370 eligible individuals must enroll. Those who wish to participate can do so at Columbia University Medical Center or New york University Langone Medical Center."
Is this a widespread or localized study?
"To limit the inconvenience of travel, please enroll at the location nearest to you from the 10 sites currently recruiting patients. These locations include New york, Chicago and Boston among others."
Could I potentially qualify to participate in this research?
"Up to 370 individuals with mci will be enrolled in this study. These participants must be between 55 and 90 years old and meet the following requirements: Abnormal memory function as documented by a score within the education-adjusted ranges on the Logical Memory II subscale (Delayed Paragraph Recall, Paragraph A only) from the Wechsler Memory Scale-Revised., Clinical Dementia Rating 0.5. The memory box score must be at least 0.5., General cognition and functional performance that is preserved enough such that a diagnosis of Alzheimer's disease cannot be made by the site physician at the time of screening visit"
Who else is applying?
What state do they live in?
How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
What questions have other patients asked about this trial?
Why did patients apply to this trial?
How responsive is this trial?
Most responsive sites:
- Boston University: < 24 hours
- Wake Forest University Health Sciences: < 24 hours
- Georgetown University: < 24 hours
Typically responds via
Average response time
- < 2 Days
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