Treatment for Multiple Sclerosis

St. Michael's Hospital, Toronto, Canada
Multiple Sclerosis
Eligibility
10 - 25
All Sexes
What conditions do you have?
Select

Study Summary

This trial will test whether metformin can be taken at different points during a 12-month period to see if it is effective.

Eligible Conditions
  • Multiple Sclerosis

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 1 & 2

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Metformin 500 Mg Oral Tablet, up to 4 tablets a day

Study Objectives

5 Primary · 4 Secondary · Reporting Duration: 3 years

3 years
Number of patients enrolled in the study compared to the number of patients who were able to complete study measures (tolerability with outcome measures)
Number of patients who were approached to participate, declined participation and consented to participate (recruitment)
Number of patients with adverse events (safety and tolerability)
Optical Coherence Tomography (OCT) - Ganglion Cell Inner Plexiform Layer Thickness
Optical Coherence Tomography (OCT) - Optic Nerve Head Volume
Optical Coherence Tomography (OCT) - Retinal Nerve Fiber Layer Thickness
Proportion of patients who completed each of the outcome measures at the appropriate time points (adherence with outcome measures)
Proportion of patients who completed each visit within the trial (retention)
Visual Evoked Potentials (VEP) - p100

Trial Safety

Phase-Based Safety

1 of 3

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Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 20 Other Conditions
This treatment demonstrated efficacy for 20 other conditions.

Trial Design

0 Treatment Group

30 Total Participants · 0 Treatment Group

Primary Treatment: Treatment · Has Placebo Group · Phase 1 & 2

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 3 years

Who is running the clinical trial?

The Hospital for Sick ChildrenLead Sponsor
648 Previous Clinical Trials
6,920,957 Total Patients Enrolled
5 Trials studying Multiple Sclerosis
211 Patients Enrolled for Multiple Sclerosis
Unity Health TorontoOTHER
510 Previous Clinical Trials
377,477 Total Patients Enrolled
4 Trials studying Multiple Sclerosis
909 Patients Enrolled for Multiple Sclerosis
Multiple Sclerosis Society of CanadaOTHER
13 Previous Clinical Trials
941 Total Patients Enrolled
13 Trials studying Multiple Sclerosis
941 Patients Enrolled for Multiple Sclerosis
Ontario Institute for Regenerative MedicineUNKNOWN
1 Previous Clinical Trials
29 Total Patients Enrolled
Stem Cell NetworkOTHER
6 Previous Clinical Trials
230 Total Patients Enrolled
Queen's UniversityOTHER
346 Previous Clinical Trials
112,083 Total Patients Enrolled
7 Trials studying Multiple Sclerosis
581 Patients Enrolled for Multiple Sclerosis
E. Ann Yeh, MA, MD, FRCPC, Dip ABPNPrincipal InvestigatorThe Hospital for Sick Children
1 Previous Clinical Trials
56 Total Patients Enrolled
1 Trials studying Multiple Sclerosis
56 Patients Enrolled for Multiple Sclerosis

Eligibility Criteria

Age 10 - 25 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a history of multiple sclerosis and have experienced vision problems in the past 6 months due to damage in the front part of your optic nerve, or had a recent relapse of the disease.
You have a level of disability measured by EDSS between 0 and 6.0.
References

Frequently Asked Questions

Have any other studies been conducted regarding this therapeutic intervention?

"Currently, there are 170 clinical trials related to this intervention in action and 43 of them have advanced to Phase 3. Though many tests for this treatment begin in Pittsburgh, PA, they span across 1903 medical sites globally." - Anonymous Online Contributor

Unverified Answer

Is there an opportunity to partake in this medical experiment?

"The requirements to be accepted into this trial are a diagnosis of multiple sclerosis and an age range between 10-25. A maximum of 30 patients will be chosen for the clinical research." - Anonymous Online Contributor

Unverified Answer

In what clinical scenarios is this therapy commonly employed?

"This particular treatment is known to be an efficacious remedy for exercise-induced stress, type 1 diabetes mellitus, and diabetic ketoacidosis." - Anonymous Online Contributor

Unverified Answer

Is the age limit for enrolment in this trial over 45?

"Patients applying to this medical trial must range in age from 10 to 25. There are 64 trials specifically targeting minors and 524 for people over the retirement age of 65." - Anonymous Online Contributor

Unverified Answer

How many participants are participating in the present clinical trial?

"Assertively, clinicaltrials.gov has information that attests to the fact this medical study is in search of participants. It was made available on February 24th 2020 and its most recent update occurred March 15th 2021; it requires 30 patients distributed across 2 different sites." - Anonymous Online Contributor

Unverified Answer

Are there still slots available for participation in this clinical trial?

"Indeed, the trial is presently open for enrollment as per reports found on clinicaltrials.gov. This research began enrolling participants back in February 2020 and was recently refreshed on March 15th 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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