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Immobilization for Muscle Atrophy

N/A

Recruiting

Research Sponsored by Queen's University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up -2, 0 (-4, 0, and 4 hours), and 10 days

Awards & highlights

Study Summary

This trial discusses the importance of skeletal muscle in maintaining overall health and how it is influenced by factors like exercise, diet, and inactivity. The study aims to understand the mechanisms that control skeletal muscle size

Who is the study for?

This trial is for healthy individuals interested in how muscles change with exercise and rest. Participants should be willing to undergo resistance training and have one leg immobilized temporarily. Specific eligibility details are not provided, but typically, participants must meet certain health standards.Check my eligibility

What is being tested?

The study looks at the effects of resistance exercise on muscle proteins compared to the effects of not using a muscle (immobilization). It aims to understand how muscles grow stronger with exercise and weaken when they're not used.See study design

What are the potential side effects?

Since this trial involves common physical activities like exercising or resting a limb, side effects might include typical workout-related discomfort such as muscle soreness or stiffness from immobilization.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ -2, 0 (-4, 0, and 4 hours), and 10 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~-2, 0 (-4, 0, and 4 hours), and 10 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and -2, 0 (-4, 0, and 4 hours), and 10 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in average rates of muscle synthesis

Dynamic proteomic profiling

Secondary outcome measures

Muscle torque

Protein expression (phosphorylation and content) of novel and known targets implicated in protein translation and mitochondrial-related protein expression

Quadriceps skeletal muscle volume

Trial Design

2Treatment groups

Experimental Treatment

Group I: Resistance TrainingExperimental Treatment1 Intervention

Participants will undergo 4 sessions of unilateral resistance training over a 10 day period (the resistance training protocol will include 3 sets of 8-12 reps of leg press and leg extension). All participants will complete this protocol. On day 0, participants will be asked to undergo a bout of unilateral resistance exercise, and the investigators will assess the acute response to exercise + protein feeding (via EAA supplement).

Group II: ImmobilizationExperimental Treatment1 Intervention

Participants will undergo 10 days of unilateral immobilization whereby a leg will remain in 60 degrees of flexion with the use of a brace. All participants will complete this protocol.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Queen's UniversityLead Sponsor

366 Previous Clinical Trials

118,523 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this medical study have eligibility criteria that include individuals above the age of 60?

"Prospective participants must be between 18 and 30 years old to meet the age requirements for enrollment in this study."

Answered by AI

Are participants currently being enrolled in this clinical trial?

"As detailed on clinicaltrials.gov, this medical study is actively seeking volunteers. The trial was initially published on April 1st, 2024 and last revised on the same date."

Answered by AI

What is the current number of participants enrolled in this clinical study?

"Affirmative. Data available on clinicaltrials.gov indicates that this investigation is presently in search of suitable candidates. The trial was first listed on 4/1/2024 and last revised on the same date. It aims to enroll 14 participants across a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse

Dr. Chris McGlory, PhD 2024. "Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06350591.

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