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This trial will test if metformin is a safe treatment for people with multiple sclerosis that is getting worse.
- Multiple Sclerosis
Inclusion CriteriaYou will be eligible if you check “Yes” for the criteria below
Study ObjectivesOutcome measures can provide a clearer picture of what you can expect from a treatment.
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Who is running the clinical trial?
- You have experienced a return of your medical condition within the past year.You have had a new type 2 lesion or a lesion that lights up with gadolinium dye in the past 12 months.You have taken glucocorticoid medications for reasons other than preparing for a specific type of treatment in the past six months.You have changed your disease treatment in the last three months.You are planning to switch your current medication for your condition.You cannot have an MRI or are unable to handle an MRI.You are taking metformin for reasons other than the intended purpose of this study.Your kidneys are not working well (GFR < 60).Your liver function tests show that your liver is not working properly.You have low levels of vitamin B12.You had a bad reaction to metformin before.You have congestive heart failure.You have a history of drinking too much alcohol.You have a condition called metabolic acidosis.You are taking other medications that may interact with metformin.You had a bad reaction to metformin before.You must be between 30 and 65 years old.You have a specific type of multiple sclerosis that is defined by certain medical guidelines from 2017.You plan to keep taking your current medication for multiple sclerosis during the trial.
- Group 1: Metformin Treatment
- Group 2: Placebo Treatment
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does the study's protocol accept minors for participation?
"Eligibility for this research study is limited to people aged between 30 and 65."
What is the total number of participants for this research endeavor?
"Affirmative, according to the information published on clinicaltrials.gov, this medical study is currently looking for volunteers. Since April 26th 2022 when it was first posted and until May 2nd 2022 when its data were last updated, 44 participants need to be found at a single research site."
Are there any opportunities for volunteers to join this experiment?
"Yes, according to clinicaltrials.gov this research endeavor is currently looking for individuals to join the study – it was first posted on April 26th 2022 and most recently updated May 2nd of the same year. 44 participants are expected at a single site."
Does my candidacy qualify me to take part in this experiment?
"44 participants, aged between 30 and 65 years old with a diagnosis of either Primary Progressive Multiple Sclerosis or Secondary Progressive Multiple Sclerosis according to the McDonald Criteria (2017), are sought for this trial. Additionally, each individual must consent to partake in the study and maintain their current MS-specific treatment protocol throughout its duration."
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