Metformin for Progressive Multiple Sclerosis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing metformin, a diabetes medication, to see if it can help adults aged 30-65 with progressive multiple sclerosis. The goal is to find out if metformin can reduce inflammation and protect nerve cells, potentially slowing down the disease.
Do I have to stop taking my current medications for the trial?
The trial requires that you continue your current MS disease-modifying treatment throughout the study. However, if you are taking medications that interact with metformin, you may need to stop those. The protocol does not specify other medication changes.
How does the drug Metformin differ from other treatments for progressive multiple sclerosis?
Metformin is unique in the treatment of progressive multiple sclerosis because it is traditionally used for managing type 2 diabetes, and its use in MS is being explored for its potential effects on cellular metabolism and inflammation, which are different from the typical immunomodulatory drugs like interferons and glatiramer acetate.12345
What evidence supports the effectiveness of the drug metformin for treating progressive multiple sclerosis?
Who Is on the Research Team?
Kevin R Patel, MD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for people aged 30-65 with Progressive Multiple Sclerosis who have been stable on their current MS treatment for at least three months. They must not have had a clinical relapse or new lesions in the past year and should not be using metformin for other conditions, nor have kidney or liver issues, B12 deficiency, heart failure, alcohol abuse, metabolic acidosis, or plans to become pregnant.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Titration
Participants are titrated from 500 mg to 2,000 mg of metformin over a 30-day period
Treatment
Participants receive metformin or placebo for the duration of the trial
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Metformin
- Placebo
Metformin is already approved in United States, Canada, Japan, China, Switzerland, European Union for the following indications:
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
- Type 2 diabetes
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor