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Transcranial Electric Stimulation

Brain Stimulation for Improving Working Memory (TravelingTES Trial)

N/A
Recruiting
Led By Ivan Alekseichuk, PhD
Research Sponsored by University of Minnesota
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age between 18 and 45 years old
Be between 18 and 65 years old
Must not have
History of head injuries with loss of consciousness
Metal or electric implant in the head, neck, or chest area
Timeline
Screening 3 weeks
Treatment Varies
Follow Up immediate effect during stimulation
Awards & highlights
No Placebo-Only Group

Summary

This trial will test if applying weak electrical currents to the scalp can improve memory in adults by creating moving waves in brain activity. The technique has been studied for its potential to enhance memory and other cognitive functions.

Who is the study for?
This trial is for adults aged 18-45 with a good grasp of English. It's not suitable for those with chronic neurological or mental disorders, head injuries causing unconsciousness, ongoing medical conditions needing drugs, pregnant or breastfeeding individuals, substance addicts, or people with metal/electric implants in the upper body.
What is being tested?
The study is testing how traveling-wave transcranial electric stimulation (tACS), a non-invasive brain stimulation technique, affects working memory performance in healthy adults.
What are the potential side effects?
Possible side effects of tACS may include mild headaches, itching or tingling at the electrode sites during stimulation. More serious risks are rare but can include seizures and other neurological symptoms.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 45 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had a head injury that made me lose consciousness.
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I have a metal or electric implant in my head, neck, or chest.
Select...
I am on long-term medication for a health condition.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~immediate effect during stimulation
This trial's timeline: 3 weeks for screening, Varies for treatment, and immediate effect during stimulation for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes in working memory performance
Secondary study objectives
Changes in electroencephalographic (EEG) connectivity
Changes in reaction time

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Group I: Parietofrontal Slow Theta StimulationExperimental Treatment1 Intervention
Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min.
Group II: Parietofrontal Fast Theta StimulationExperimental Treatment1 Intervention
Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces parietal-to-frontal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min.
Group III: Frontoparietal Slow Theta StimulationExperimental Treatment1 Intervention
Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 4 Hz with the intensity of up to 2 mA and duration up to 20 min.
Group IV: Frontoparietal Fast Theta StimulationExperimental Treatment1 Intervention
Participants will receive multi-electrode transcranial alternating current stimulation over the prefrontal and parietal brain regions that induces frontal-to-parietal traveling wave at the frequency of 7 Hz with the intensity of up to 2 mA and duration up to 20 min.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Transcranial alternating current stimulation (tACS)
2020
N/A
~20

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Treatments for working memory, such as traveling wave transcranial alternating current stimulation (tACS), work by modulating neural activity through the application of electrical currents to the brain. This modulation can enhance or inhibit neuronal firing patterns, improving synaptic plasticity and connectivity in brain regions like the prefrontal cortex, which are critical for working memory. For patients, these mechanisms are important as they offer potential improvements in cognitive functions, thereby enhancing their ability to perform daily tasks and improving overall quality of life.

Find a Location

Who is running the clinical trial?

University of MinnesotaLead Sponsor
1,427 Previous Clinical Trials
1,620,549 Total Patients Enrolled
1 Trials studying Working Memory
16 Patients Enrolled for Working Memory
Brain & Behavior Research FoundationOTHER
62 Previous Clinical Trials
2,897 Total Patients Enrolled
Ivan Alekseichuk, PhDPrincipal InvestigatorUniversity of Minnesota

Media Library

Transcranial Alternating Current Stimulation (tACS) (Transcranial Electric Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT05399381 — N/A
Working Memory Research Study Groups: Parietofrontal Slow Theta Stimulation, Parietofrontal Fast Theta Stimulation, Frontoparietal Slow Theta Stimulation, Frontoparietal Fast Theta Stimulation
Working Memory Clinical Trial 2023: Transcranial Alternating Current Stimulation (tACS) Highlights & Side Effects. Trial Name: NCT05399381 — N/A
Transcranial Alternating Current Stimulation (tACS) (Transcranial Electric Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05399381 — N/A
~1 spots leftby Dec 2024