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Vitamin C for Thermal Burns (VICToRY Trial)

Phase 3
Recruiting
Led By Daren K Heyland, MD
Research Sponsored by Clinical Evaluation Research Unit at Kingston General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18 years of age or older
Minimum burn size of ≥ 20% Total Body Surface Area (TBSA)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

VICToRY Trial Summary

This trial will test whether high doses of vitamin C can improve outcomes for burn patients.

Who is the study for?
Adults with severe burns covering at least 20% of their body, who need skin grafting, can join this trial. They must be able to start treatment within 24 hours of being admitted to the hospital and not already receiving high-dose IV vitamin C. Pregnant or lactating individuals, those expected not to survive the next 72 hours, with a recent history of kidney stones or certain deficiencies cannot participate.Check my eligibility
What is being tested?
The VICToRY Trial is testing if high-dose intravenous vitamin C can help critically ill burn patients recover faster and have better survival rates compared to standard care alone. Half will receive vitamin C along with standard care while the other half gets a placebo alongside standard treatment.See study design
What are the potential side effects?
Potential side effects from high-dose IV vitamin C may include digestive discomfort and an increased risk for kidney stones in susceptible individuals.

VICToRY Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.
Select...
My burns cover 20% or more of my body.
Select...
I have deep burns that need skin grafting.

VICToRY Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Persistent Organ Dysfunction + Death
Time to discharge alive from hospital
Secondary outcome measures
PODS+death
Time to Discharge Alive
Other outcome measures
6 month mortality
Duration of mechanical ventilation
Gram negative bacteremia
+6 more

Side effects data

From 2019 Phase 4 trial • 66 Patients • NCT02209636
38%
Non-serious adverse events
3%
Hospitalization
100%
80%
60%
40%
20%
0%
Study treatment Arm
Lanthanum Carbonate
Placebo
Placebo- Phosphorus Balance Sub-study
Lanthanum Carbonate- Phosphorus Balance Sub-study

VICToRY Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin CExperimental Treatment1 Intervention
Patients will receive intravenous vitamin C at 50mg/kg every 6 hours for 96 hours
Group II: Control groupPlacebo Group1 Intervention
Patients will receive a similar amount of placebo (either D5W or saline) delivered in the same manner as the vitamin C.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ascorbic Acid
2017
Completed Phase 4
~2240

Find a Location

Who is running the clinical trial?

Clinical Evaluation Research Unit at Kingston General HospitalLead Sponsor
15 Previous Clinical Trials
3,670 Total Patients Enrolled
Dr. Christian Stoppe, MD, Co-Principal Investigator, Wurzburg University, Wurzburg, GermanyUNKNOWN
Daren K Heyland, MDPrincipal InvestigatorQueen's University
10 Previous Clinical Trials
4,607 Total Patients Enrolled

Media Library

Ascorbic Acid Clinical Trial Eligibility Overview. Trial Name: NCT04138394 — Phase 3
Thermal Burns Research Study Groups: Vitamin C, Control group
Thermal Burns Clinical Trial 2023: Ascorbic Acid Highlights & Side Effects. Trial Name: NCT04138394 — Phase 3
Ascorbic Acid 2023 Treatment Timeline for Medical Study. Trial Name: NCT04138394 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could you elaborate on Ascorbic Acid's role in other medical research?

"Ascorbic Acid was first studied in 2007 by the Medical University of Vienna. In the time since, there have been a grand total of 2848 completed studies. Right now, there are 56 clinical trials in progress that are actively recruiting patients. A significant portion of these studies are based in Québec and Montreal."

Answered by AI

What is the total number of hospitals that are conducting this experiment?

"To facilitate ease of participation, this trial is recruiting patients from 13 sites located in Québec, Ohio City, Phoenix and other cities. By selecting the location nearest to you, you can minimize travel demands."

Answered by AI

Is it safe to take Ascorbic Acid supplements?

"Ascorbic acid is considered safe based on data from Phase 2 clinical trials. However, efficacy has not been established."

Answered by AI

What does Ascorbic Acid help to treat?

"Vitamin A deficiency is often treated with ascorbic acid. However, ascorbic acid can also be used to mitigate other conditions such as vitamin deficiency and supplementation."

Answered by AI

Are people still able to sign-up for this clinical trial?

"Yes, you are correct. The clinical trial is currently recruiting patients, as noted on clinicaltrials.gov. This trial was posted on July 24th, 2020 and was updated on August 22nd, 2020. The study needs a total of 180 participants, which will be recruited from 13 different locations."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
VItamin C in Thermal injuRY: The VICToRY Trial
Daren K. Heyland 2020. "VItamin C in Thermal injuRY: The VICToRY Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04138394.
~272 spots leftby Dec 2026
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