Vitamin C for Thermal Burns
(VICToRY Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study aims to show that giving high dose, intravenous vitamin C in addition to standard care to burned critically ill patients will be associated with less organ dysfunction, improved survival and a quicker rate of recovery. In this study, all patients will receive standard care and of the patients will also receive high dose intravenous vitamin C, while the other half of patients will receive placebo.
Will I have to stop taking my current medications?
The trial protocol does not specify if you need to stop taking your current medications. However, if you are receiving high-dose IV vitamin C or using hydroxycobalamin (vitamin B12) for suspected cyanide poisoning, you may not be eligible to participate.
Is high-dose vitamin C safe for treating burns?
How does high-dose vitamin C treatment differ from other treatments for thermal burns?
What data supports the effectiveness of the drug Ascorbic Acid for treating thermal burns?
Who Is on the Research Team?
Daren K Heyland, MD
Principal Investigator
Queen's University
Are You a Good Fit for This Trial?
Adults with severe burns covering at least 20% of their body, who need skin grafting, can join this trial. They must be able to start treatment within 24 hours of being admitted to the hospital and not already receiving high-dose IV vitamin C. Pregnant or lactating individuals, those expected not to survive the next 72 hours, with a recent history of kidney stones or certain deficiencies cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive high-dose intravenous vitamin C or placebo for 96 hours
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants' health-related quality of life and mortality are assessed
What Are the Treatments Tested in This Trial?
Interventions
- Ascorbic Acid
- placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Clinical Evaluation Research Unit at Kingston General Hospital
Lead Sponsor
Dr. Christian Stoppe, MD, Co-Principal Investigator, Wurzburg University, Wurzburg, Germany
Collaborator