Study Summary
This trial is studying ascorbic acid combined with chemo to treat lymphoma that has returned or is unresponsive to therapy. Ascorbic acid may make cancer cells more sensitive to chemo.
- Clonal Cytopenia of Undetermined Significance
- Hodgkin Lymphoma
- Diffuse Large B-Cell Lymphoma
- Diffuse Large B Cell Lymphoma (DLBCL)
- Refractory Lymphomas
- Recurrent Lymphoma
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
3 Primary · 7 Secondary · Reporting Duration: Up to 2 years
Trial Safety
Phase-Based Safety
Side Effects for
Awards & Highlights
Trial Design
5 Treatment Groups
Arm B (placebo, combination chemotherapy)
1 of 5
Arm D (ascobic acid)
1 of 5
Arm C (ascorbic acid and combination chemotherapy)
1 of 5
Arm D (ascorbic acid)
1 of 5
Arm A (ascorbic acid, combination chemotherapy)
1 of 5
Active Control
Experimental Treatment
55 Total Participants · 5 Treatment Groups
Primary Treatment: Rituximab · Has Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 1 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
How many different medical clinics are conducting this study?
"Currently, patients are being enrolled at the University of Iowa/Holden Comprehensive Cancer Center in Iowa City, Iowa; Mayo Clinic Health System-Franciscan Healthcare in La Crosse, Wisconsin; and Mayo Clinic in Rochester. Other centres include: ____ , ____ , ____ , ____ , and ___ ." - Anonymous Online Contributor
Does Rituximab have FDA backing?
"While there is some data suggesting Rituximab is safe, as this is only a Phase 2 trial, there is no clinical evidence yet of its efficacy. Thus, it received a score of 2." - Anonymous Online Contributor
What is the aim of this research?
"The aim of this study, which will take place over the course of 2 years, is to ORR (Arm C). Additionally, we will also be measuring secondary outcomes including overall survival and incidence of adverse events." - Anonymous Online Contributor
What are the most popular applications for Rituximab?
"Rituximab has been clinically shown to be effective in the treatment of merkel cell cancer, leukemia, and synovitis." - Anonymous Online Contributor
How many individuals are being treated as part of this medical study?
"A total of 147 patients that satisfy the pre-determined inclusion criteria are needed for this clinical trial. Two locations where patients can participate in this study include University of Iowa/Holden Comprehensive Cancer Center and Mayo Clinic Health System-Franciscan Healthcare." - Anonymous Online Contributor
Is this research still looking for participants?
"That is correct, the online clinical trials database does show that this study is currently open for recruitment. According to the information available, the trial was first posted on March 23rd, 2018 and was last updated on May 26th, 2022. The researchers running the trial are looking to enroll 147 patients at 5 different locations." - Anonymous Online Contributor
What other scientific papers have been published that mention Rituximab?
"Currently, 872 out of 3375 total clinical trials studying Rituximab are in Phase 3. The majority of these investigations into the efficacy of this treatment are based in Guangzhou, Guangdong. However, there are a total 130821 locations worldwide running studies related to Rituximab." - Anonymous Online Contributor