Remote ischemic preconditioning for Heart Failure

Phase-Based Progress Estimates
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh, PAHeart Failure+4 MoreRemote ischemic preconditioning - Device
All Sexes
What conditions do you have?

Study Summary

This trial is studying whether a treatment called remote ischemic preconditioning can reduce contrast-associated acute kidney injury, functional capacity, and major adverse kidney events in patients with congestive heart failure undergoing cardiac catheterization and/or percutaneous coronary intervention.

Eligible Conditions
  • Heart Failure
  • Percutaneous Coronary Intervention (PCI)
  • Acute Kidney Injury
  • Prophylaxis of Contrast-induced Nephropathy
  • Coronary Angiography

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: 3 months

1 month
6 minute walk distance
Hour 48
Brain Natriuretic Peptide (BNP)
Contrast-associated acute kidney injury
3 months
Major adverse kidney events

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Remote ischemic preconditioning
1 of 2
Sham remote ischemic preconditioning
1 of 2

Active Control

Non-Treatment Group

240 Total Participants · 2 Treatment Groups

Primary Treatment: Remote ischemic preconditioning · Has Placebo Group · Phase 2 & 3

Sham remote ischemic preconditioning
ShamComparator Group · 1 Intervention: Sham remote ischemic conditioning · Intervention Types: Device
Remote ischemic preconditioning
ActiveComparator Group · 1 Intervention: Remote ischemic preconditioning · Intervention Types: Device

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 3 months

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,494 Previous Clinical Trials
2,724,074 Total Patients Enrolled
33 Trials studying Heart Failure
61,330 Patients Enrolled for Heart Failure
Oladipupo Olafiranye, MDPrincipal InvestigatorVA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
1 Previous Clinical Trials
110 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 6 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have either a suspected stable heart disease or are currently experiencing a heart attack.

Frequently Asked Questions

How many individuals are taking part in this clinical research?

"The most recent information on says that this trial is still recruiting patients. The posting date was 11/1/2021, and the last update occurred on 11/2/2022. There are plans to enroll 240 participants at 2 locations." - Anonymous Online Contributor

Unverified Answer

Are we currently looking for new participants in this clinical trial?

"This research project is still recruiting test subjects, with the first posting on being November 1st, 2021 and the most recent update coming on November 2nd, 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.