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Exercise + Amino Acid Infusion for Obesity

N/A
Recruiting
Led By Lori R Roust, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 9 hours on 2 separate days one month apart
Awards & highlights

Study Summary

This trial will investigate how well exercise and amino acids can help improve protein homeostasis in people with obesity who have a distorted expression of myosin heavy chain protein.

Who is the study for?
This trial is for adults with obesity, having a BMI of 32-50 kg/m2. They must be able to consent to the study and should not have acute illnesses, liver or severe heart disease, low blood counts, recent steroid use, extreme diets like veganism, or be on weight-loss regimens. Smokers and pregnant individuals are excluded.Check my eligibility
What is being tested?
The trial investigates how exercise combined with amino acid infusions affects muscle protein regulation in obese individuals. It aims to understand how these interventions can correct protein imbalances linked to poor health outcomes in obesity.See study design
What are the potential side effects?
Potential side effects may include discomfort at the infusion site, allergic reactions to amino acids, muscle soreness from exercise routines, and possible gastrointestinal issues due to changes in metabolism.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~9 hours on 2 separate days one month apart
This trial's timeline: 3 weeks for screening, Varies for treatment, and 9 hours on 2 separate days one month apart for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Eukaryotic initiation factor 4F (eIF4F)
Change in Protein Synthesis
Change in messenger RNA (mRNA)
Secondary outcome measures
Change in Protein breakdown

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Exercise, Infusion of Amino AcidsExperimental Treatment2 Interventions
Exercise followed by infusion of amino acids, or infusion of amino acids alone.
Group II: ExerciseActive Control1 Intervention
Exercise with no infusion of amino acids

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,208 Previous Clinical Trials
3,766,956 Total Patients Enrolled
84 Trials studying Obesity
14,629 Patients Enrolled for Obesity
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH
2,359 Previous Clinical Trials
4,315,401 Total Patients Enrolled
446 Trials studying Obesity
588,844 Patients Enrolled for Obesity
Lori R Roust, MDPrincipal InvestigatorMayo Clinic

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT04700800 — N/A
Obesity Research Study Groups: Exercise, Infusion of Amino Acids, Exercise
Obesity Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT04700800 — N/A
Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT04700800 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still availability to enroll in this research experiment?

"This clinical trial, which was initially published on October 7th 2021, is actively searching for participants. Its details were recently updated as of June 6th 2022."

Answered by AI

Who can take part in this experiment?

"To qualify for this clinical trial, applicants must be aged 18 to 45 and have a BMI of 30 or higher. Currently, 94 patients are needed to complete the study."

Answered by AI

Is the upper age limit for this trial beyond 45 years?

"To qualify for this medical experiment, applicants must be between 18 and 45 years old. For those under 18 or over 65, there are 202 and 597 studies respectively available to them."

Answered by AI

What is the current capacity for participants in this clinical research?

"Affirmative, according to the information posted on clinicaltrials.gov this investigation is currently enrolling participants. The trial was initially made public on October 7th 2021 and has been updated as recently as June 6th 2022. 94 patients must be recruited from a single site in order for the study to reach its goal."

Answered by AI

Who else is applying?

What site did they apply to?
Mayo Clinic in Arizona
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
Regulation of Muscle Protein Phenotype in Humans With Obesity
Lori R. Roust 2021. "Regulation of Muscle Protein Phenotype in Humans With Obesity". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04700800.
~3 spots leftby Jun 2024
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