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Lifestyle Intervention for High Blood Pressure (EPIPHANY Trial)

N/A
Recruiting
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Not taking any antihypertensive medication
No history of cardiovascular disease, diabetes, or chronic kidney disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 6 months,12 months, 18 months
Awards & highlights

EPIPHANY Trial Summary

This trial is testing an intervention to lower blood pressure in rural Black adults in Alabama, who have some of the highest rates in the US. The intervention includes group health education, online cooking and exercise classes, and support from health coaches.

Who is the study for?
This trial is for Black/African American adults living in rural Alabama with slightly elevated blood pressure, but not high enough to require medication. Participants should be under 65 years old without a history of heart disease, diabetes, or kidney issues and must speak English. They can't join if they're pregnant, planning to move soon, or don't have a phone.Check my eligibility
What is being tested?
The study tests whether health education and peer support interventions delivered through churches can lower blood pressure among rural Black adults. Half the churches offer group education and online resources; the other half adds personalized telephone coaching from trained church members.See study design
What are the potential side effects?
Since this trial focuses on lifestyle changes like diet improvements and increased physical activity rather than medications, side effects are minimal but may include muscle soreness from exercise or changes in digestion due to dietary adjustments.

EPIPHANY Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am not on any blood pressure medication.
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I have no history of heart disease, diabetes, or kidney problems.

EPIPHANY Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 6 months,12 months, 18 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 6 months,12 months, 18 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Incident Blood Pressure
Secondary outcome measures
Alcohol use
Fruit/Vegetable/Fiber Intake
Physical Activity
+1 more

EPIPHANY Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Health Education & Peer CoachingExperimental Treatment3 Interventions
Participants will have access to online health education materials and will also be matched with a community health worker who will offer support through peer coaching
Group II: Health Education OnlyActive Control2 Interventions
Participants will have access to online health education materials but will not receive individualized peer support
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Health Education
2014
Completed Phase 3
~4010

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,591 Previous Clinical Trials
2,281,194 Total Patients Enrolled

Media Library

Community-Level Peer Support Clinical Trial Eligibility Overview. Trial Name: NCT05367544 — N/A
High Blood Pressure Research Study Groups: Health Education & Peer Coaching, Health Education Only
High Blood Pressure Clinical Trial 2023: Community-Level Peer Support Highlights & Side Effects. Trial Name: NCT05367544 — N/A
Community-Level Peer Support 2023 Treatment Timeline for Medical Study. Trial Name: NCT05367544 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals currently being enrolled into this experimental research?

"Correct. Clinicaltrials.gov indicates that this clinical trial, which was first made available on August 13th 2022, is currently seeking participants. The total number of patients required for the study to be valid is 528 and it will take place at a single medical centre."

Answered by AI

How many participants have been accepted into this experiment?

"Indeed, the clinicaltrials.gov website lists this trial as currently open to enrolment since August 13th 2022 and modified on 8/18/2022. This study is slated to recruit 528 patients from a single site."

Answered by AI

Who else is applying?

What state do they live in?
Alabama
How old are they?
18 - 65
What site did they apply to?
University of Alabama At Birmingham
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
Equity in Prevention and Progression of Hypertension by Addressing Barriers to Nutrition and Physical activitY
Andrea Cherrington, MD 2022. "Equity in Prevention and Progression of Hypertension by Addressing Barriers to Nutrition and Physical activitY". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05367544.
~202 spots leftby Jul 2025
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