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Regorafenib for Thyroid Cancer
Study Summary
This trial is studying regorafenib to see how well it works in treating patients with thyroid cancer that has spread to other parts of the body and cannot be removed by surgery.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 1 & 2 trial • 495 Patients • NCT02024607Trial Design
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Who is running the clinical trial?
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- I have a history of bleeding or clotting disorders.I am 18 years old or older.I am experiencing mild to severe dehydration.I do not have a severe ongoing infection.I do not have any serious heart conditions.I have no other cancers except for treated skin, superficial bladder cancer, or in-situ cervical cancer.I have brain or meningeal tumors that are causing symptoms.I currently have symptoms of interstitial lung disease.I have been diagnosed with pheochromocytoma.I have severe protein in my urine.I have previously received treatment specifically targeting my cancer.I have not had radiation in the last 14 days and do not need dialysis.I have a condition that affects how my body absorbs nutrients.I am not receiving any cancer treatments other than the study treatment.I am on blood thinners like warfarin or heparin.I am currently using herbal remedies like St. John's Wort.My thyroid cancer has spread and was confirmed by a lab test.I can provide a tissue sample from my cancer for testing.My recent tests show my bone marrow, liver, and kidneys are functioning well.I am not pregnant or incapable of becoming pregnant.I have HIV or hepatitis B/C that needs antiviral treatment.I have previously taken regorafenib.My high blood pressure is not controlled even with medication.I haven't had major surgery or a serious injury in the last 28 days.I am fully active and can carry on all pre-disease activities without restriction.I haven't taken any tyrosine kinase inhibitors recently.I have a non-healing wound or fracture not caused by cancer.I have had previous chemotherapy or targeted therapy treatments.I have not had severe bleeding in the last 4 weeks.I have had an organ transplant.I have been treated with regorafenib before.I am not pregnant or breast-feeding.I can swallow and keep down pills.I haven't had major surgery or a serious injury in the last 28 days.I agree to use birth control from the start of the study until 2 months after the last dose.You must have at least one area of the body where the disease can be accurately measured according to specific guidelines.My cancer has worsened in the last 6 months according to scans.I have fluid in my chest or abdomen causing significant breathing problems.I haven't had a stroke, clot, or embolism in the last 6 months.I am on medication for seizures.
- Group 1: Regorafenib
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is this experiment the inaugural exploration of its kind?
"Regorafenib has been a subject of research since 2014, when Bayer conducted its first clinical trial with 38 participants. Subsequently, the medication was granted Phase 2 drug approval and today 58 ongoing studies are being carried out in 418 cities across 30 countries."
Have Regorafenib experiments been documented elsewhere?
"Currently, 58 clinical trials are studying regorafenib. Out of these studies, 7 are currently in Phase 3 and 1205 sites across the world are running them. Most of these research locations lie within Commack, New york."
For what medical conditions is Regorafenib prescribed as a treatment?
"Regorafenib is typically utilized to manage the effects of anti-VEGF drugs, in addition to providing relief for patients suffering from advanced directives, sorafenib, and unresectable gastrointestinal stromal tumors."
Are there any opportunities for participants to join this trial?
"Indeed, the clinicaltrial.gov information confirms that this clinical trial is actively searching for participants across 1 site. The study was first published on January 1st 2016 and last edited on February 18th 2022, with a goal of recruiting 33 patients."
To what degree has Regorafenib demonstrated safe use among humans?
"We evaluated Regorafenib's safety to be a 2 on the 1-3 scale as it is currently in Phase 2, with some evidence of its safety but not yet any proof of efficacy."
What is the current threshold for enrollment in this clinical trial?
"Confirmed. According to information on clinicaltrials.gov, this study is actively enrolling participants and was first posted in January 2016. The trial needs 33 patients at a single site for completion; the latest update occurred February 18th 2022."
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