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MORPH for Sedentary Lifestyle (MORPH-II Trial)

N/A
Waitlist Available
Led By Jason Fanning, PhD
Research Sponsored by Wake Forest University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Self-reported pain in 2 or more of the following sites on most days for the previous 3 months: back, neck, shoulders, hips and/or knees
Age 55-85 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to week 24
Awards & highlights

MORPH-II Trial Summary

This trial is a study to see if a mobile intervention can help reduce pain and improve health in obese adults with chronic pain. The intervention will be delivered over 12 weeks and will include a focus on dietary weight loss plus movement across the day. The investigators hope that the intervention will help participants achieve a greater number of steps through conventional walking exercise, allowing for less pain intensity, and better physical function.

Who is the study for?
This trial is for older adults aged 55-85 with obesity (BMI of 30-45), chronic pain in multiple areas, and a sedentary lifestyle. They must have stable weight, data coverage at home, agree to the study's procedures, and own a smartphone.Check my eligibility
What is being tested?
MORPH II tests a fully remote intervention aimed at reducing pain and promoting movement throughout the day using high-contact coaching via tablet computers. It compares this approach against standard control over 12 weeks to see if it improves pain, physical function, activity levels, and reduces sitting time.See study design
What are the potential side effects?
Since MORPH II involves non-pharmacological interventions focusing on diet changes and increased movement facilitated by technology and coaching rather than medication or surgery, no direct side effects are expected from the intervention itself.

MORPH-II Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have had pain in my back, neck, shoulders, hips, or knees for the last 3 months.
Select...
I am between 55 and 85 years old.

MORPH-II Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to week 24
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to week 24 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Pain Intensity
Pain Interference
Sedentary time
Secondary outcome measures
Steps
Other outcome measures
Physical Function

MORPH-II Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: MORPHExperimental Treatment1 Intervention
Participants engage in 12 weeks of group and 1-on-1 coaching meant to promote physical activity throughout the day and caloric restriction. Participants engage with a custom smartphone application, use a smart scale and physical activity monitor, and meet using video conference software. At the end of 12 weeks, participants are provided with tools to continue meeting virtually on their own if desired, and will be followed for an additional 12-week maintenance phase.
Group II: ControlActive Control1 Intervention
This condition receives the wearable activity monitor and simply asked to use it and continue in their daily lives for 24 weeks.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
MORPH
2018
N/A
~40

Find a Location

Who is running the clinical trial?

Wake Forest UniversityLead Sponsor
187 Previous Clinical Trials
153,493 Total Patients Enrolled
1 Trials studying Sedentary Lifestyle
183 Patients Enrolled for Sedentary Lifestyle
Jason Fanning, PhDPrincipal Investigator - Wake Forest University
Wake Forest University
1 Previous Clinical Trials
30 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~11 spots leftby Mar 2025