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Genetic Counseling for Thyroid Cancer
N/A
Recruiting
Led By Junne Kamihara, MD, PhD
Research Sponsored by Dana-Farber Cancer Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Pediatric patient with current or previous known or suspected thyroid cancer or nodule(s)
Individuals from families with a high suspicion of hereditary thyroid cancer, including those with a current or previous diagnosis of thyroid cancer/nodule occurring in childhood (<18 years old), thyroid cancer in multiple individuals, thyroid cancer and a known genetic syndrome, and thyroid cancer and a suspected genetic syndrome (e.g. multiple childhood cancers in the family, multiple primary cancers, multiple endocrinopathies, etc.)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years
Awards & highlights
Study Summary
This trial looks at families with a history of thyroid cancer to try and understand what causes the cancer and how it can be prevented.
Who is the study for?
This trial is for children and adults with current or past thyroid cancer or nodules, especially if there's a strong suspicion that the condition might be inherited. It includes those from families where multiple members had thyroid cancer, associated genetic syndromes, or various cancers at a young age.Check my eligibility
What is being tested?
The study involves collecting family and medical history information along with blood or saliva samples to understand genetic factors contributing to thyroid cancer risk. Participants may also be referred to a genetic counselor if needed.See study design
What are the potential side effects?
There are no direct side effects from participating in this study as it does not involve drug treatments. However, providing blood samples can sometimes result in bruising, bleeding, or infection at the puncture site.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am a child with current or past thyroid cancer or nodules.
Select...
My family has a history of thyroid cancer, including cases in childhood or alongside genetic syndromes.
Select...
I have or might have thyroid cancer, or nodules, with a family history of cancer.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 2 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Number of germline mutations identified associated with thyroid cancer predisposition
Number of participants who have childhood or suspected familial thyroid nodules/cancer
Prevalence of suspected familial thyroid cancer among those with childhood thyroid nodules/cancer
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Higher Suspected Familial PredispositionExperimental Treatment1 Intervention
Higher Suspected Familial Predisposition
Screening and Enrollment:
Consent, Family HX, Medical HX, Blood/Saliva which will categorize by suspected hereditary predisposition: Based on family and medical history.
- Specimen Testing and Analysis
•Referral to Genetic Counselor, if indicated
Group II: Lower Suspected Familial PredispositionActive Control1 Intervention
Lower Suspected Familial Predisposition
Screening and Enrollment:
Consent, Family HX, Medical HX, Blood/Saliva which will categorize by suspected hereditary predisposition: Based on family and medical history.
- Sample stored in Biorepository
Find a Location
Who is running the clinical trial?
Dana-Farber Cancer InstituteLead Sponsor
1,072 Previous Clinical Trials
340,156 Total Patients Enrolled
Junne Kamihara, MD, PhDPrincipal Investigator - Dana-Farber Cancer Institute
Boston Children's Hospital, Dana-Farber Cancer Institute
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I am a child with current or past thyroid cancer or nodules.My family has a history of thyroid cancer, including cases in childhood or alongside genetic syndromes.I have or might have thyroid cancer, or nodules, with a family history of cancer.I am able to understand and agree to the study's procedures and risks.
Research Study Groups:
This trial has the following groups:- Group 1: Higher Suspected Familial Predisposition
- Group 2: Lower Suspected Familial Predisposition
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any enrolment opportunities in this clinical trial currently available?
"Affirmative. On clinicaltrials.gov, the trial is listed as actively recruiting participants, which began on March 1st 2016 and was last updated on May 4th 2022. The study requires 250 patients to be recruited from a single medical centre."
Answered by AI
What is the participant enrollment rate for this research endeavor?
"Indeed, according to clinicaltrials.gov, this trial is in the process of enrolling participants. It was launched on March 1st 2016 and last modified on May 4th 2022. The desired number of patients is 250, all from a single medical centre."
Answered by AI
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