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Anti-Inflammatory Drug + Pain Challenge for Pain
Study Summary
This trial will study whether a new bio-signature (a range of pro- and anti-nociceptive IL-1 family cytokine activity) can predict pain and release of endogenous opioids in healthy subjects. Another objective is to see if an anti-inflammatory drug (minocycline) will reduce pain during the experimental, nociceptive pain challenge.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
Media Library
- Group 1: Anakinra plus nociceptive pain challenge, then placebo plus nociceptive pain challenge
- Group 2: Placebo plus nociceptive pain challenge, then anakinra plus nociceptive pain challenge
Frequently Asked Questions
Is there an age cap for participants in this research?
"Enrollees of this study must be over 18 years old and below the age of 65."
Could you provide a synopsis of the research conducted in regards to Nociceptive pain stimulation?
"Presently, there are 33 investigations into Nociceptive pain challenge; 7 of those studies have reached Phase 3. Over 440 trial locations exist globally with the majority being within Paris, Ile-De-France."
To what ailments does Nociceptive pain challenge typically offer relief?
"Nociceptive pain challenge is a popular approach for treating Systemic Juvenile Idiopathic Arthritis (sjia), but it may also be effective in managing Neonatal-Onset Multisystem Inflammatory Disease (nomid) and other conditions involving interleukin-1 receptors or steroids."
To what degree is Nociceptive pain challenge a secure treatment for patients?
"Our team has judged the safety of Nociceptive pain challenge as moderately low, given that this Phase 1 trial contains a limited amount of data regarding its efficacy and safety."
Do I qualify to partake in this clinical experiment?
"This medical research is searching for 70 people aged 18 to 65 that are experiencing pain. Notably, the trial participants must be either obese or non-obese and they should have an upcoming elective surgical procedure."
How many participants have signed up for this experiment?
"Affirmative. According to the data uploaded on clinicaltrials.gov, this trial began accepting applicants on 19th of July 2021 and has since been revised once as of January 19th 2022. The research necessitates 70 participants recruited from one location only."
Are there current openings for participants in this research endeavor?
"Affirmative. Clinicaltrials.gov reveals that this clinical investigation, which was initially publicized on July 19th 2021, is now recruiting volunteers. Approximately 70 people are required to be recruited from one location."
Who else is applying?
What state do they live in?
How old are they?
What portion of applicants met pre-screening criteria?
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How many prior treatments have patients received?
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