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Baricitinib for Pediatric COVID-19 (COV-BARRIER Trial)
COV-BARRIER Trial Summary
This trial will test if the drug baricitinib can help treat children in the hospital with COVID-19 and what the right dose is.
COV-BARRIER Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowCOV-BARRIER Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.COV-BARRIER Trial Design
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Who is running the clinical trial?
Frequently Asked Questions
What does this trial hope to achieve for participating patients?
"The primary objective of this clinical trial, which will be measured over a Day 1 and Day 4 time span, is to assess the Maximum Concentration (Cmax) of Baricitinib. Furthermore, this trial will also be evaluating secondary outcomes includingOverall improvement on the NIAID-OS, Percentage of Participants Who Require Noninvasive Ventilation/high-flow oxygen or Invasive Mechanical Ventilation (including extracorporeal membrane oxygenation [ECMO]), and Percentage of Participants with at Least 1-Point Improvement on National Institute of Allergy and Infectious Diseases Ordinal Scale (NIAID-OS"
What are the known dangers of Baricitinib?
"There is some data to support the efficacy of Baricitinib, and multiple rounds of data support its safety, so our team at Power has given it a safety rating of 3."
What are the prerequisites for subjects in this research?
"Eligible patients for this coronavirus clinical trial must have contracted the disease and be between 2 and 18 years of age. There is space for approximately 24 patients."
What other research projects have there been on Baricitinib?
"Currently, there are 34 active clinical trials testing Baricitinib. Of these, 17 are in Phase 3. Although several trials for Baricitinib are based in Pune, Maharashtra, there are 1,438 total locations for these studies."
Could you tell me how many hospitals in Canada are participating in this clinical trial?
"There are 9 recruiting patients for this study at locations such as University of Virginia Health System in Charlottesville, The University of Mississippi Medical Center in Jackson, and Children's Hospital of Michigan in Detroit,as well as 9 other locations."
Does this research only include participants under the age of 30?
"According to the terms set by the researchers, the minimum age for this clinical trial is 2 years old while the maximum age is 18 years old."
For what medical purpose is Baricitinib most commonly prescribed?
"Baricitinib is often used to treat patients who are hospitalized. Additionally, this medication can be useful in managing other conditions like coronavirus disease 2019 (covid‑19), ecmo treatment, and rheumatoid arthritis."
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