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Radiation Therapy

Stereotactic Radiosurgery for Spinal Cord Compression

Phase 1
Waitlist Available
Led By Amol J. Ghia, MD
Research Sponsored by M.D. Anderson Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Maximum of 3 contiguous vertebral levels involved with metastasis in the spine to be irradiated in a single session
Greater than or equal to 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 12 months following radiation
Awards & highlights

Study Summary

This trial will test whether a single session of radiation can effectively treat metastatic epidural spinal cord compression.

Who is the study for?
This trial is for adults over 18 with inoperable, unirradiated metastatic epidural spinal cord compression confirmed by MRI. Candidates must have a certain level of physical function (KPS >/= 40) and motor strength (>/= 4/5), and can't be pregnant or intolerant to lying flat for extended periods. It's not for those with radiosensitive cancers like lymphoma or prior spine irradiation.Check my eligibility
What is being tested?
The study tests the feasibility of using a single session of spine stereotactic radiosurgery (SSRS) to treat patients with specific types of cancer that have spread to the spinal cord, affecting up to three contiguous vertebral levels.See study design
What are the potential side effects?
While side effects are not detailed here, SSRS may cause skin irritation at the treatment site, fatigue, temporary pain flare-ups, nausea, and potential damage to nearby organs or tissues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My spine cancer affects up to 3 connected vertebrae.
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I am 18 years old or older.
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I can care for myself but may not be able to do active work.
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My muscle strength in the limbs affected by spinal compression is mostly preserved.
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My MRI shows cancer has spread to my spine, affecting it.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 12 months following radiation
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 12 months following radiation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Occurrences of Paralysis caused by Radiation Myelitis (RM)

Trial Design

1Treatment groups
Experimental Treatment
Group I: Stereotactic Radiosurgery (SSRS)Experimental Treatment1 Intervention
Target dose of 18 or 24 Gy to spine in single session of radiation treatment.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Stereotactic Radiosurgery (SSRS)
2010
Completed Phase 1
~20

Find a Location

Who is running the clinical trial?

M.D. Anderson Cancer CenterLead Sponsor
2,958 Previous Clinical Trials
1,798,296 Total Patients Enrolled
Amol J. Ghia, MDPrincipal InvestigatorM.D. Anderson Cancer Center
5 Previous Clinical Trials
353 Total Patients Enrolled

Media Library

Spine Stereotactic Radiosurgery (SSRS) (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT01254903 — Phase 1
Epidural Spinal Cord Compression Research Study Groups: Stereotactic Radiosurgery (SSRS)
Epidural Spinal Cord Compression Clinical Trial 2023: Spine Stereotactic Radiosurgery (SSRS) Highlights & Side Effects. Trial Name: NCT01254903 — Phase 1
Spine Stereotactic Radiosurgery (SSRS) (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT01254903 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~3 spots leftby Apr 2025