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Beta Blocker

Propranolol for Hypoxia

Phase < 1
Recruiting
Led By Jacqueline K Limberg, Ph.D.
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Aged 18-45 years
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to 5 minutes
Awards & highlights

Study Summary

This trial will investigate how different sexes respond to hypoxia, or low oxygen levels.

Who is the study for?
This trial is for healthy adults, both men and women aged between 18-45 with a BMI of 18-30. Participants must not be pregnant, breastfeeding, or using nicotine products. Those with high blood pressure, nerve diseases, diabetes, PCOS, drug use issues, recent COVID-19 symptoms, sleep apnea or major organ diseases are excluded.Check my eligibility
What is being tested?
The study aims to understand how low oxygen levels affect blood vessel responses differently in men and women by comparing the effects of a Propranolol pill (a beta-blocker) versus a placebo (inactive pill).See study design
What are the potential side effects?
Propranolol may cause dizziness, fatigue, cold hands/feet due to reduced heart rate and blood pressure; less commonly it can cause shortness of breath or insomnia. Placebos typically have no active ingredients but can lead to perceived side effects.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 45 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to 5 minutes
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to 5 minutes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Forearm Blood Flow

Trial Design

1Treatment groups
Experimental Treatment
Group I: Hypoxia ExposureExperimental Treatment2 Interventions
Men and women will be exposed to isocapnic hypoxia. Participants will wear a mask and systemic oxygen levels will be titrated to attain hypoxemia as assessed by pulse oximetry.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propranolol Pill
2015
Completed Phase 3
~90
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
361 Previous Clinical Trials
627,959 Total Patients Enrolled
3 Trials studying Hypoxia
154 Patients Enrolled for Hypoxia
American Heart AssociationOTHER
324 Previous Clinical Trials
4,933,743 Total Patients Enrolled
2 Trials studying Hypoxia
60 Patients Enrolled for Hypoxia
Jacqueline K Limberg, Ph.D.Principal InvestigatorUniversity of Missouri-Columbia
3 Previous Clinical Trials
119 Total Patients Enrolled
1 Trials studying Hypoxia
54 Patients Enrolled for Hypoxia

Media Library

Propranolol Hydrochloride (Beta Blocker) Clinical Trial Eligibility Overview. Trial Name: NCT05256069 — Phase < 1
Hypoxia Research Study Groups: Hypoxia Exposure
Hypoxia Clinical Trial 2023: Propranolol Hydrochloride Highlights & Side Effects. Trial Name: NCT05256069 — Phase < 1
Propranolol Hydrochloride (Beta Blocker) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05256069 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are individuals aged 65 or older eligible for enrollment in this trial?

"To comply with the stipulated requirements of this study, eligible participants must be aged 18 to 45."

Answered by AI

Are any participants still needed for this research experiment?

"Affirmative. Clinicaltrials.gov exhibits that this experiment, initially posted on February 1st 2023 and most recently updated 11/11/2022, is actively seeking participants. 35 individuals are being sought after at a single medical site."

Answered by AI

Who meets the criteria to be eligible for enrollment in this medical experiment?

"Qualified participants must express vasodilation and be between 18-45 years old. This research study is expected to recruit up to 35 patients."

Answered by AI

To what extent is the scope of this clinical trial limited by a participant quota?

"Affirmative. Clinicaltrials.gov indicates that this research is in the process of enrolling participants, with an initial posting date of February 1st 2023 and a latest update on November 11th 2022. The investigation is attempting to recruit 35 individuals from one medical centre."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
University of Missouri-Columbia
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I would like be be a volunteer.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia
Jacqueline K Limberg, PhD 2023. "Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05256069.
~18 spots leftby Apr 2025
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