Increased Water Intake + Diet for Weight Control in Older Adults
Trial Summary
What is the purpose of this trial?
This study is a randomized controlled intervention trial in adults aged 50+ years with overweight or obesity, which will compare three groups with different diet prescriptions: 1) pre-meal water consumption (500 ml, before each main meal) with a hypocaloric diet; 2) 1500 ml water consumed throughout the day with a hypocaloric diet; 3) hypocaloric diet with no instructions regarding water consumption. Smart water bottles will objectively assess water intake timing and volume. Urine osmolality, urine volume, and serum osmolality will be used as objective indicators of compliance with the water intake prescription. We will investigate changes in perceived hunger and fullness and appetite-regulating hormones as potential mechanisms by which premeal water could improve appetite regulation. We will also investigate the impact of water consumption and hydration on executive function capabilities, which may influence intervention adherence. Although increasing water intake could be an effective weight management strategy, no evidence-based recommendations exist for the timing of water intake needed for this benefit.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are on medications that impact gastrointestinal function, you may not be eligible to participate.
What data supports the effectiveness of the treatment for weight control in older adults?
Is increased water intake with a diet safe for weight control in older adults?
How does the treatment of increased water intake and diet for weight control in older adults differ from other treatments?
This treatment is unique because it combines increased water intake, specifically drinking 500 mL of water before meals, with a low-calorie diet to enhance weight loss in older adults. Unlike other weight loss methods, this approach leverages the natural appetite-suppressing effect of water, making it a simple and low-risk strategy for managing weight.23468
Research Team
Brenda M Davy, PhD, RD
Principal Investigator
Virginia Polytechnic Institute and State University
Eligibility Criteria
This trial is for people over 50 who are overweight or obese, with a BMI of 25-40 and stable weight in the last six months. It's not suitable for those with certain medical conditions like uncontrolled high blood pressure, special diet needs due to diseases like diabetes, allergies to specific foods in the test meals, or a history of gastrointestinal issues.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Weight Loss Phase
Participants follow a hypocaloric diet with varying water intake prescriptions to assess changes in body weight, appetite hormones, and executive function
Weight Loss Maintenance Phase
Participants continue with the prescribed diet and water intake to maintain weight loss and assess long-term changes in hydration status and executive function
Follow-up
Participants are monitored for safety and effectiveness after the main intervention phases
Treatment Details
Interventions
- Water Intake and weight control in older adults - hypocaloric diet alone
- Water intake and weight control in older adults - Premeal Water + hypocaloric diet
- Water intake and weight control in older adults - Total Daily Water + hypocaloric diet
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Who Is Running the Clinical Trial?
Virginia Polytechnic Institute and State University
Lead Sponsor