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Adaptive Radiation Dose Escalation for Non-Small Cell Lung Cancer (PET-BOOST Trial)
PET-BOOST Trial Summary
This trial is testing whether a higher dose of radiation to areas of the tumor that are more active will reduce the rate of the cancer coming back in 2 years.
PET-BOOST Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPET-BOOST Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.PET-BOOST Trial Design
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Who is running the clinical trial?
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- I have another active cancer besides lung cancer.I have had radiotherapy in the areas where I now need treatment.I had surgery as part of my cancer treatment plan.I can care for myself and am up and about more than 50% of my waking hours.Your liver function tests show that AST, ALT, or total bilirubin levels are more than 2.5 times higher than the normal range.I am 18 years or older and can give my consent.I do not have severe heart issues, recent serious infections, severe lung problems, or AIDS.I will be treated with both chemotherapy and radiation as my main treatment.My tumor or lymph node is at least 10mm large as shown on a CT scan.You are currently pregnant.My lung function is significantly below normal.My recent blood tests show low white blood cells, platelets, or hemoglobin.I have lost more than 10% of my weight without trying over the last 3 months.I need assistance with my daily activities.You have a tumor that shows high uptake of a special imaging substance called FDG on a PET scan.
- Group 1: Chemoradiotherapy
- Group 2: Chemoradiotherapy with Integrated Boost Dose
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many locales are currently overseeing this clinical endeavor?
"Currently, there are 7 medical centres hosting this clinical trial. Out of the participating sites, some cities include London, Quebec and Newmarket with additional locations available too. It is advised to select a nearby clinic in order to decrease travel demands for participants."
Are any new individuals being enrolled in this trial at the present time?
"Per the clinicaltrials.gov website, patient recruitment for this study is still in progress; it was first launched on May 1st 2016 and its details were last updated on April 7th 2022."
What is the total cohort size of this experiment?
"This trial necessitates the enrolment of 78 qualified individuals. Prospective participants can apply at London Regional Cancer Program in London, Ontario or CHU de Quebec - L'Hôtel-Dieu de Québec in Quebec, Ont."
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