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Virus Therapy

RiMO-301 With Radiation for Cancer

Phase 1
Recruiting
Research Sponsored by Coordination Pharmaceuticals, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of advanced or metastatic cancer not amenable to curative therapy
Target tumor in region not in previously irradiated field
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 45 days
Awards & highlights

Study Summary

This trial will test the safety and effectiveness of RiMO-301, a new drug, in combination with radiation in patients with advanced tumors.

Who is the study for?
Adults over 18 with advanced or metastatic cancer that can't be cured, who have recovered from previous treatments and are not pregnant. The tumor must be measurable, suitable for radiotherapy, and accessible for direct injection. Patients with lymphomas/leukemias or recent therapies/surgeries are excluded.Check my eligibility
What is being tested?
The trial is testing RiMO-301 combined with radiation on patients with advanced tumors. It's an early-phase study to find the right dose of RiMO-301 when injected directly into the tumor alongside standard radiotherapy.See study design
What are the potential side effects?
Since this is a Phase I trial primarily focused on determining the appropriate dosage of RiMO-301, specific side effects aren't listed but may include typical reactions to cancer drugs such as fatigue, pain at injection site, and potential radiation-related skin changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cancer is advanced or has spread and cannot be cured with surgery or other treatments.
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My target tumor is not in an area that was previously treated with radiation.
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I am not pregnant, not breastfeeding, and I use birth control.
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My cancer can be treated with radiation to ease symptoms.
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My cancer can be targeted with radiation and is reachable for direct injection.
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I am older than 18 years.
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I have at least one tumor that can be measured.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~45 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 45 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum Tolerated Dose (MTD)
Secondary outcome measures
Area Under the Curve [AUC]
Maximum Plasma Concentration [Cmax]
adverse effect
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: RiMO-301+RadiotherapyExperimental Treatment1 Intervention
3 dose levels (5%, 10%, and 15% of the total baseline tumor volume, respectively) will be tested in a 3 + 3 dose escalation study

Find a Location

Who is running the clinical trial?

Coordination Pharmaceuticals, Inc.Lead Sponsor
5 Previous Clinical Trials
110 Total Patients Enrolled
Rimo Therapeutics Inc.Lead Sponsor
University of ChicagoOTHER
1,004 Previous Clinical Trials
819,773 Total Patients Enrolled
3 Trials studying Tumors
191 Patients Enrolled for Tumors

Media Library

RiMO-301 (Virus Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03444714 — Phase 1
Tumors Research Study Groups: RiMO-301+Radiotherapy
Tumors Clinical Trial 2023: RiMO-301 Highlights & Side Effects. Trial Name: NCT03444714 — Phase 1
RiMO-301 (Virus Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03444714 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Phase I Study of RiMO-301 With Radiation in Advanced Tumors
2018. "Phase I Study of RiMO-301 With Radiation in Advanced Tumors". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03444714.
~1 spots leftby Sep 2024
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