KITE-363/KITE-753 for B-cell Lymphoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing the safety and proper dosage of two new drugs, KITE-363 and KITE-753, in patients whose B-cell lymphoma has returned or not responded to other treatments. The goal is to find out if these drugs can effectively target and kill the resistant cancer cells.
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Who Is on the Research Team?
Kite Study Director
Principal Investigator
Kite, A Gilead Company
Are You a Good Fit for This Trial?
This trial is for people with B-cell lymphoma that has come back or hasn't responded to treatment. They must have at least one measurable lesion, good organ and bone marrow function, and no major health issues like heart disease or active infections. People with HIV, hepatitis B/C, recent serious blood clots, CNS disorders, or a history of certain other cancers aren't eligible.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment Phase 1a (Dose Escalation)
Participants receive lymphodepleting chemotherapy followed by a single target starting dose of KITE-363 or KITE-753. Additional participants are enrolled based on dose limiting toxicities observed.
Treatment Phase 1b (Dose Expansion)
After dose escalation, additional participants receive lymphodepleting chemotherapy followed by a single dose of KITE-363 or KITE-753 at a tolerable dose level.
Follow-up
Participants are monitored for safety and effectiveness after treatment, transitioning to a long-term follow-up study for 15 years.
What Are the Treatments Tested in This Trial?
Interventions
- Cyclophosphamide
- Fludarabine
- KITE-363
Find a Clinic Near You
Who Is Running the Clinical Trial?
Kite, A Gilead Company
Lead Sponsor