114 Participants Needed

KITE-363/KITE-753 for B-cell Lymphoma

Recruiting at 14 trial locations
MI
Overseen ByMedical Information
Age: 18+
Sex: Any
Trial Phase: Phase 1
Sponsor: Kite, A Gilead Company
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial is testing the safety and proper dosage of two new drugs, KITE-363 and KITE-753, in patients whose B-cell lymphoma has returned or not responded to other treatments. The goal is to find out if these drugs can effectively target and kill the resistant cancer cells.

Will I have to stop taking my current medications?

The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

Who Is on the Research Team?

KS

Kite Study Director

Principal Investigator

Kite, A Gilead Company

Are You a Good Fit for This Trial?

This trial is for people with B-cell lymphoma that has come back or hasn't responded to treatment. They must have at least one measurable lesion, good organ and bone marrow function, and no major health issues like heart disease or active infections. People with HIV, hepatitis B/C, recent serious blood clots, CNS disorders, or a history of certain other cancers aren't eligible.

Inclusion Criteria

My B-cell lymphoma has returned or did not respond to treatment.
At least 1 measurable lesion
My organs and bone marrow are functioning well.

Exclusion Criteria

I have a history of HIV, hepatitis B, or hepatitis C.
My leukemia or lymphoma has changed into a more aggressive form.
Primary immunodeficiency
See 11 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment Phase 1a (Dose Escalation)

Participants receive lymphodepleting chemotherapy followed by a single target starting dose of KITE-363 or KITE-753. Additional participants are enrolled based on dose limiting toxicities observed.

4 weeks

Treatment Phase 1b (Dose Expansion)

After dose escalation, additional participants receive lymphodepleting chemotherapy followed by a single dose of KITE-363 or KITE-753 at a tolerable dose level.

4 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment, transitioning to a long-term follow-up study for 15 years.

15 years

What Are the Treatments Tested in This Trial?

Interventions

  • Cyclophosphamide
  • Fludarabine
  • KITE-363
Trial Overview The study is testing the safety and proper dosing of two drugs: KITE-363 and KITE-753 in participants with relapsed/refractory B-cell lymphoma. It includes preparatory chemotherapy (Cyclophosphamide and Fludarabine) before administering the study drugs.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Group I: KITE-753Experimental Treatment3 Interventions
Group II: KITE-363Experimental Treatment3 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Kite, A Gilead Company

Lead Sponsor

Trials
45
Recruited
4,300+
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security