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Behavioral Intervention

Alert for Dyslipidemia (PAD-ALERT Trial)

N/A

Recruiting

Led By Gregory Piazza

Research Sponsored by Brigham and Women's Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 6 months

Awards & highlights

PAD-ALERT Trial Summary

This trial is being conducted at one hospital with 400 patients. It will test a computerized tool called EPIC Best Practice Advisory to see if it can help doctors and patients follow guidelines for using stat

Who is the study for?

This trial is for patients with Peripheral Artery Disease (PAD) who are not currently taking medication to lower LDL cholesterol. It's designed to see if a computer alert can help improve the use of recommended treatments.Check my eligibility

What is being tested?

The study tests an electronic alert system that reminds healthcare providers and patients about the benefits of statins or alternative therapies for lowering cholesterol in PAD patients not on treatment.See study design

What are the potential side effects?

Since this trial focuses on a decision support tool rather than a drug, there aren't direct side effects from the intervention itself. However, any prescribed lipid-lowering therapy will have its own potential side effects.

PAD-ALERT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Frequency of prescription of oral LDL-C-lowering therapy

Secondary outcome measures

Change in LDL-C level

Other outcome measures

Frequency of all-cause hospitalization

Frequency of all-cause mortality

Frequency of major adverse cardiovascular events

+1 more

PAD-ALERT Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: AlertExperimental Treatment1 Intervention

Alert-based CDS will consist of an on-screen electronic alert that will notify the clinician that the patient has an indication for LDL-C-lowering therapy but is not prescribed any. The clinician will have the opportunity to proceed to an order template through which appropriate lipid-lowering can be prescribed. The clinician could also elect to learn more about current evidence-based recommendations for LDL-C lowering in the PAD population. Finally, the clinician could elect to proceed without ordering oral LDL-C-lowering therapy or reading evidence-based recommendations for LDL-C lowering but would have to provide a rationale for not doing so.

Group II: No AlertActive Control1 Intervention

No on-screen notification will be issued to the clinician

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Brigham and Women's HospitalLead Sponsor

1,616 Previous Clinical Trials

11,470,550 Total Patients Enrolled

1 Trials studying Dyslipidemia

10,544 Patients Enrolled for Dyslipidemia

Esperion Therapeutics, Inc.Industry Sponsor

25 Previous Clinical Trials

21,518 Total Patients Enrolled

1 Trials studying Dyslipidemia

177 Patients Enrolled for Dyslipidemia

Gregory PiazzaPrincipal InvestigatorBWH

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current number of individuals being enrolled in this research investigation?

"Indeed, as indicated on clinicaltrials.gov, this particular medical research is actively seeking suitable candidates. The trial was initially posted on March 1st, 2023 and underwent its latest update on March 7th, 2024. Recruitment aims to enlist a total of 400 participants from one designated site."

Answered by AI

Are eligible patients able to enroll in this ongoing trial at the present time?

"According to the details on clinicaltrials.gov, this research is actively seeking eligible participants. The trial was first listed on March 1st, 2023 and last revised on March 7th, 2024."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy

Gregory Piazza 2023. "Randomized Controlled Trial of Alert-Based Computerized Decision Support for Patients With Peripheral Artery Disease Not Prescribed Lipid-Lowering Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06300450.

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