Hypertonic Saline for Salt Sensitivity of Blood Pressure

Phase-Based Progress Estimates
William B Farquhar, Newark, DE
Salt Sensitivity of Blood Pressure+1 More
Hypertonic Saline - Other
18 - 65
All Sexes
What conditions do you have?

Study Summary

The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pressure regulation, which has major public health implications.

Eligible Conditions

  • Salt Sensitivity of Blood Pressure

Treatment Effectiveness

Effectiveness Progress

1 of 3

Other trials for Salt Sensitivity of Blood Pressure

Study Objectives

2 Primary · 0 Secondary · Reporting Duration: 1 hour

1 hour
Functional MRI

Trial Safety

Safety Progress

1 of 3

Other trials for Salt Sensitivity of Blood Pressure

Trial Design

2 Treatment Groups

Functional Magnetic Resonance Imaging
1 of 2
Salt Sensitivity Assessment
1 of 2
Experimental Treatment

40 Total Participants · 2 Treatment Groups

Primary Treatment: Hypertonic Saline · No Placebo Group · N/A

Functional Magnetic Resonance Imaging
Experimental Group · 1 Intervention: Hypertonic Saline · Intervention Types: Other
Salt Sensitivity Assessment
Experimental Group · 1 Intervention: Dietary Intervention · Intervention Types: Other

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1 hour
Closest Location: William B Farquhar · Newark, DE
Photo of delaware 1Photo of delaware 2Photo of delaware 3
2019First Recorded Clinical Trial
1 TrialsResearching Salt Sensitivity of Blood Pressure
2 CompletedClinical Trials

Who is running the clinical trial?

University of DelawareLead Sponsor
130 Previous Clinical Trials
36,410 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 4 Total Inclusion Criteria

Mark “yes” if the following statements are true for you:
You have a blood pressure of at least 100/60 mmHg and <130/80 mmHg.
You have a BMI of 18.5 kg/m2 - 30 kg/m2.
The serum potassium level is between 3.5 mmol/L and 5.5 mmol/L.

About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.