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Sodium Intake Modification for High Blood Pressure

Q: What is the current recruitment number for participants in this experiment?

<p>Affirmative. Clinicaltrials.gov informs us that this trial is still open for recruitment, with the first post dating back to June 1st 2022 and the last edit on July 27th 2022. The team behind it is looking for 40 volunteers from a single site.</p>

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Recruiting

Research Sponsored by University of Delaware

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 hour

Awards & highlights

Study Summary

This trial will help identify regions of the brain that help regulate blood pressure in response to changes in sodium levels.

Who is the study for?

This trial is for adults aged 18-45 with normal blood pressure and potassium levels, who have a BMI within the range of 18.5 to 30 kg/m2. It's designed for those without any known allergies or salt sensitivity issues that affect their blood pressure.Check my eligibility

What is being tested?

The study aims to understand how the brain detects changes in blood sodium levels and its role in controlling blood pressure. Participants will undergo dietary interventions and receive hypertonic saline to identify key brain regions involved in sodium sensing.See study design

What are the potential side effects?

Potential side effects may include discomfort from high salt intake such as thirst, increased urination, dizziness, or elevated blood pressure due to the hypertonic saline solution.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 hour

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 hour

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 hour for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Plasma arginine vasopressin concentration (pg/mL)

fMRI to assess SFO-OLVT functional connectivity (z-score)

Trial Design

2Treatment groups

Experimental Treatment

Group I: Salt Sensitivity AssessmentExperimental Treatment1 Intervention

1 week high salt diet and 1 week low salt diet

Group II: Functional Magnetic Resonance ImagingExperimental Treatment1 Intervention

Hypertonic saline infusion perturbation with and without NKCC2 antagonism (furosemide) to examine sodium sensing mechanisms

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of DelawareLead Sponsor

154 Previous Clinical Trials

25,171 Total Patients Enrolled

Media Library

Hypertonic Saline Clinical Trial Eligibility Overview. Trial Name: NCT05480722 — N/A

Salt Sensitivity of Blood Pressure Research Study Groups: Salt Sensitivity Assessment, Functional Magnetic Resonance Imaging

Salt Sensitivity of Blood Pressure Clinical Trial 2023: Hypertonic Saline Highlights & Side Effects. Trial Name: NCT05480722 — N/A

Hypertonic Saline 2023 Treatment Timeline for Medical Study. Trial Name: NCT05480722 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants for this research limited to persons of legal age?

"This trial requires that prospective participants are between 18 and 45 years old."

Answered by AI

Are there still opportunities to join this research initiative?

"As per information on clinicaltrials.gov, this experiment is accepting participants at the moment. This research began being posted to the website in June of 2022 and was most recently updated in July that same year."

Answered by AI

Is eligibility to join this experiment open at present?

"For this study, 40 participants aged 18 to 45 are sought out who have been identified as being salt-sensitive in regards to blood pressure. Furthermore, they must meet the following criteria: Age: 18 - 45 years; Blood Pressure: >100/60 mmHg and <130/80 mmHg; BMI: 18.5 kg/m2 - 30 kg/m2; Serum Potassium Level 3.5 mmol/L – 5.5 mmol/L"

Answered by AI

What is the current recruitment number for participants in this experiment?

"Affirmative. Clinicaltrials.gov informs us that this trial is still open for recruitment, with the first post dating back to June 1st 2022 and the last edit on July 27th 2022. The team behind it is looking for 40 volunteers from a single site."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Central Sodium Sensing: Implications for Blood Pressure Regulation

William Farquhar 2022. "Central Sodium Sensing: Implications for Blood Pressure Regulation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05480722.

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