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Sacubitril/Valsartan for Metabolic Health in Black Individuals
Study Summary
This trial will test whether a medication can help improve the metabolic health of black individuals by augmenting natriuretic peptide levels.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Logistics
Other reimbursement is provided
Other forms of reimbursement are provided for this trial.
Who is running the clinical trial?
Media Library
- You identify yourself as African-American or Black.I am 18 years old or older.You are unable to walk or run on a treadmill.I have diabetes or my blood sugar/HbA1C levels are high.You identify as African-American or Black.You have a blood pressure of 120-160/80-100 mmHg.I have smoked in the past year.You drink more than two alcoholic drinks every day.I am not pregnant, breastfeeding, and I use effective birth control or practice abstinence.You have a serious mental health condition or a history of seizures.You have a history of angioedema, which is a severe allergic reaction that causes swelling under the skin.I am 18 years old or older.I have a history of heart or blood vessel diseases.
- Group 1: Valsartan
- Group 2: Sacubitril/Valsartan
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: You will receive the treatment for 3 Months
- Follow Ups: You may be asked to continue sharing information regarding the trial for 1 Weeks after you stop receiving the treatment.
Frequently Asked Questions
What medical issues can be addressed through Exercise capacity VO2 maximum determination?
"Patients with essential hypertension, left ventricular dysfunction and insufficient response to single-drug therapy can find relief through the use of Exercise capacity VO2 maximum determination."
What would be considered a successful outcome from this research?
"This 12-week trial seeks to observe the alteration in insulin sensitivity after natriuretic peptide augmentation. Secondary objectives of this research include tracking changes in fasting insulin levels, HOMA-IR, and adipose tissue mass following pharmacological treatment over a twelve week period."
Is this clinical trial accepting new participants at the moment?
"As per information published on clinicaltrials.gov, this trial is currently recruiting patients and was first mentioned online in August 2020 with its latest update being recorded the same month two years later."
How many participants are currently receiving treatment as part of this trial?
"Indeed, the information on clinicaltrials.gov conveys that this medical experiment is presently enrolling individuals. The project was initially posted on August 15th 2020 and lastly revised on August 15th 2022. They are seeking to secure 200 research participants from a solitary institution."
Are there any health risks associated with determining the maximum oxygen uptake of a patient?
"Our team at Power assigned a score of 2 to the safety of Exercise capacity VO2 maximum determination, as this is a Phase 2 trial. This means there has been some evidence collected in support of its safety but none regarding efficacy."
Have any other explorations been conducted concerning the ability to exercise as measured by VO2 maximum?
"Currently, eight Phase 3 studies are being conducted on Exercise capacity VO2 maximum determination in Montreal, Quebec. Additionally, a total of 826 clinical centres across the globe have trials running related to this research topic."
Who else is applying?
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What portion of applicants met pre-screening criteria?
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