Sacubitril/Valsartan for Metabolic Health in Black Individuals
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests if sacubitril/valsartan can improve insulin sensitivity and energy use in Black individuals by increasing heart hormone levels. Black individuals are targeted because they often have lower levels of these hormones, leading to higher risks of diabetes. Valsartan has been studied for its potential to improve insulin sensitivity and β-cell function in various populations, including those with impaired glucose metabolism.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is Sacubitril/Valsartan safe for humans?
What makes the drug sacubitril/valsartan unique for metabolic health in Black individuals?
Sacubitril/valsartan is unique because it combines two components: sacubitril, which inhibits neprilysin (an enzyme that breaks down certain proteins), and valsartan, an angiotensin II receptor blocker, offering a novel approach to managing heart failure and potentially improving metabolic health. This combination has shown superior results in reducing heart failure risks compared to traditional treatments like enalapril.12678
What data supports the effectiveness of the drug Sacubitril/Valsartan for metabolic health in Black individuals?
Who Is on the Research Team?
Pankaj Arora, MD
Principal Investigator
University of Alabama at Birmingham
Are You a Good Fit for This Trial?
This trial is for African-American or Black adults with blood pressure between 120-160/80-100 mmHg, who are not pregnant, don't smoke, and have no history of significant heart disease or diabetes. They must be able to exercise on a treadmill and not consume more than two alcoholic drinks daily.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive sacubitril/valsartan or valsartan alone for 12 weeks to assess changes in insulin sensitivity and energy expenditure
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Sacubitril
- Valsartan
Sacubitril is already approved in European Union, United States, Canada, Japan for the following indications:
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alabama at Birmingham
Lead Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator