Weight-Loss Methods for Obesity
Trial Summary
What is the purpose of this trial?
The purpose of this study is to determine if diet-induced weight loss causes different changes in hormones that control appetite and glucose control than surgery-induced weight loss. The overall research plan is a non-randomized prospective study of 3 different weight loss (WL) interventions and a lean and an obese healthy control group.
Research Team
Judith Korner, MD, PhD
Principal Investigator
Columbia University
Eligibility Criteria
This trial is for men and women aged 18-65 struggling with obesity and insulin resistance, who haven't had significant weight changes or bariatric surgery before, don't use tobacco or opioids, aren't pregnant, and don't have untreated thyroid disease, diabetes, special diet restrictions, certain medical conditions like heart failure or Crohn's disease.Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo weight loss interventions including sleeve gastrectomy, Roux-en-Y gastric bypass, or very low calorie diet
Follow-up
Participants are monitored for changes in hormones and glycemic control after weight loss interventions
Treatment Details
Interventions
- Roux-en-Y Gastric Bypass
- Sleeve Gastrectomy
- Very Low Calorie Diet
Roux-en-Y Gastric Bypass is already approved in European Union, United States, Canada for the following indications:
- Obesity
- Type 2 Diabetes
- Metabolic Syndrome
- Obesity
- Type 2 Diabetes
- Gastroesophageal Reflux Disease (GERD)
- Obesity
- Type 2 Diabetes
- Hypertension
Find a Clinic Near You
Who Is Running the Clinical Trial?
Columbia University
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator