Study Summary
This trial will test whether a non-TBI conditioning regimen is effective for B-ALL patients with low risk of relapse as defined by NGS-MRD.
- B-cell Acute Lymphoblastic Leukemia
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 0 Secondary · Reporting Duration: Two years
Trial Safety
Safety Progress
Trial Design
0 Treatment Group
95 Total Participants · 0 Treatment Group
Primary Treatment: Treatment · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 1 - 25 · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Andolina, Jeffrey R., Carol Fries, Renee Boulware, Alyssa Vargas, Ellen Fraint, Matthew Barth, Steven Ambrusko, Melanie Comito, and Philip Monteleone. 2021. “Successful Bone Marrow Transplantation with Intensive Post-transplant Intrathecal Chemotherapy for CNS Relapsed AML in 2 Infants”. Journal of Pediatric Hematology/oncology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/mph.0000000000002151.
- Hisham Abdel-Azim 2018. "The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children, Adolescents, and Young Adults With B-ALL". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03509961.
Frequently Asked Questions
How can I sign up to participate in this research?
"Eligibility for this leukemia clinical trial requires that patients are between the ages of 1 Year and 25. The study is looking to recruit up to 95 participants." - Anonymous Online Contributor
What is the FDA's official stance on this medication?
"The safety of this treatment was given a score of 2. This is because, although there are Phase 2 trials underway that support the safety of the medication, there is currently no data to suggest that it is an effective treatment." - Anonymous Online Contributor
Does your research include elderly study participants?
"To be eligible for this particular clinical trial, patients must between the ages of 1 year and 25 years old. There are 478 other trials available for people who are younger than 18 and 1229 trials available for seniors." - Anonymous Online Contributor
How many people total are researchers testing this on?
"In order for this clinical trial to move forward, 95 eligible patients must agree to participate. Treatment will be administered at different sites across America, such as Children's Healthcare of Atlanta in Atlanta, Georgia and Riley Hospital for Children - Indiana University in Indianapolis, Indiana." - Anonymous Online Contributor
Are there any open slots for new patients in this research project?
"That is correct. The clinicaltrials.gov website says that the study is open and looking for 95 participants at 24 different hospitals or clinics." - Anonymous Online Contributor
How many test sites are there for this trial?
"Children's Healthcare of Atlanta in Georgia, Riley Hospital for Children - Indiana University , and Floating Hospital for Children at Tufts Medical Center are some of the notable locations where this study is taking place. In total, there are 28 hospitals running this trial." - Anonymous Online Contributor