Study Summary
This trial is testing a new way to treat leukemia with an unrelated umbilical cord blood transplant. The transplant will use a myeloablative preparative regimen, which will include the drugs cyclophosphamide, fludarabine, and fractionated total body irradiation.
- Leukemia
- Chronic Lymphocytic Leukemia
- Leukemia, Multiple Myeloma
- Non-Hodgkin's Lymphoma
- Small Lymphocytic Lymphoma
- Mantle Cell Lymphoma
- Myelodysplasia
- Myelofibrosis
- Lymphoplasmacytic Lymphoma
- Prolymphocytic Leukaemia
- Lymphoblastic Lymphoma
- Burkitt Lymphoma
- Marginal Zone B-Cell Lymphoma
- Follicular Lymphoma
- Multiple Myeloma
- Acute Lymphoblastic Leukemia
- Acute Myeloid Leukemia
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 9 Secondary · Reporting Duration: 1, 2 years
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
1 Treatment Group
Umbilical Cord Blood Transplant
1 of 1
Experimental Treatment
200 Total Participants · 1 Treatment Group
Primary Treatment: Total Body Irradiation · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age < 65 · All Participants · 4 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Are participants still being admitted to this research project?
"According to clinicaltrials.gov, the trial is open for enrollment at this moment in time. The study was initially posted on December 1st 2016 and most recently updated on November 2nd 2022." - Anonymous Online Contributor
Are there any other published reports assessing the efficacy of Total Body Irradiation?
"Presently, 937 studies are underway exploring Total Body Irradiation. Of these active trials, 171 have reached Phase 3. Even though the majority of research for this procedure is centered in Philadelphia, Pennsylvania there exists 28877 other testing sites across the world." - Anonymous Online Contributor
Are there any limits to the number of participants being recruited for this trial?
"Affirmative. The clinicaltrial.gov repository shows that the current status of this trial is actively recruiting, with an initial posting date on December 1st 2016 and most recent edit from November 2nd 2022. 200 participants are needed at a single site for completion of the study." - Anonymous Online Contributor
In which cases is Total Body Irradiation commonly utilized?
"Total Body Irradiation is often used for transplantation and has also been deemed an effective treatment option for multiple sclerosis, lupus nephritis, as well as acute myelocytic leukemia." - Anonymous Online Contributor