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Cord Blood Transplant for Leukemia
Study Summary
This trial is testing a new way to treat leukemia with an unrelated umbilical cord blood transplant. The transplant will use a myeloablative preparative regimen, which will include the drugs cyclophosphamide, fludarabine, and fractionated total body irradiation.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am HIV positive.My initial cancer treatment has been effective.I am between 0 and 55 years old.My large cell or high grade NHL cancer did not respond to more than 2 treatments.I've had extensive cancer treatment, including long-term alkylator therapy or radiation.I have a specific type or stage of blood cancer.I have had radiation therapy before, and it might affect my eligibility for more radiation treatment.I have had a bone marrow transplant within the last 6 months if I am under 18, or any type of bone marrow transplant if I am older than 18.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
- Group 1: Umbilical Cord Blood Transplant
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 20 Other Conditions - This treatment demonstrated efficacy for 20 other conditions.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Frequently Asked Questions
Are participants still being admitted to this research project?
"According to clinicaltrials.gov, the trial is open for enrollment at this moment in time. The study was initially posted on December 1st 2016 and most recently updated on November 2nd 2022."
Are there any other published reports assessing the efficacy of Total Body Irradiation?
"Presently, 937 studies are underway exploring Total Body Irradiation. Of these active trials, 171 have reached Phase 3. Even though the majority of research for this procedure is centered in Philadelphia, Pennsylvania there exists 28877 other testing sites across the world."
Are there any limits to the number of participants being recruited for this trial?
"Affirmative. The clinicaltrial.gov repository shows that the current status of this trial is actively recruiting, with an initial posting date on December 1st 2016 and most recent edit from November 2nd 2022. 200 participants are needed at a single site for completion of the study."
In which cases is Total Body Irradiation commonly utilized?
"Total Body Irradiation is often used for transplantation and has also been deemed an effective treatment option for multiple sclerosis, lupus nephritis, as well as acute myelocytic leukemia."
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