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Cannabinoid

Cannabis for Pain

Phase < 1
Recruiting
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age between 21-65 years old
If female and of childbearing potential age, not pregnant or nursing mothers
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at the first baseline testing session (session 1) and at the intervention session (session 2). all data will be collected within 2 weeks of signing consent.
Awards & highlights

Study Summary

This trialaims to study the brain mechanisms of cannabis to treat pain in humans, as it has been a promising therapy for many pain conditions but has yet to be clinically proven.

Who is the study for?
This trial is for adults aged 21-65 who have used cannabis before but are not currently dependent on it or using any form. They must be free from major medical conditions, psychiatric disorders like schizophrenia or bipolar disorder, and cannot be pregnant or nursing. Participants agree to avoid opioids, barbiturates, and driving within 4 hours after using study cannabis.Check my eligibility
What is being tested?
The study is testing how vaporized cannabis (active ingredient THC) versus a placebo (no active ingredient) affects pain relief by looking at the brain's response to acute pain. Researchers aim to understand the neural mechanisms behind why cannabis might alleviate pain.See study design
What are the potential side effects?
While specific side effects aren't listed here, typical reactions to cannabis may include dizziness, dry mouth, altered senses/perception, mood changes, slower reaction times and in some cases anxiety or discomfort.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 21 and 65 years old.
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I am not pregnant or breastfeeding.
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I am not taking any opioid medications.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at the first baseline testing session (session 1) and at the intervention session (session 2). all data will be collected within 2 weeks of signing consent.
This trial's timeline: 3 weeks for screening, Varies for treatment, and at the first baseline testing session (session 1) and at the intervention session (session 2). all data will be collected within 2 weeks of signing consent. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Cerebral blood flow
Secondary outcome measures
Visual Analog Scale Pain ratings

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active THCExperimental Treatment1 Intervention
Participants will be administered 400mg of vaporized cannabis (5.1%) before pain testing and fMRI.
Group II: Placebo THCPlacebo Group1 Intervention
Participants will be administered 400mg of vaporized cannabis (<.1%) before pain testing and fMRI.

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,120 Previous Clinical Trials
1,521,307 Total Patients Enrolled
11 Trials studying Acute Pain
975 Patients Enrolled for Acute Pain

Media Library

Active Cannabis (Cannabinoid) Clinical Trial Eligibility Overview. Trial Name: NCT04982965 — Phase < 1
Acute Pain Research Study Groups: Active THC, Placebo THC
Acute Pain Clinical Trial 2023: Active Cannabis Highlights & Side Effects. Trial Name: NCT04982965 — Phase < 1
Active Cannabis (Cannabinoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04982965 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical experiment permit individuals over thirty years of age to participate?

"The study has a pre-defined age range for participation with 21 being the lower threshold and 65 being the upper limit."

Answered by AI

Are there specific criteria for eligibility in this clinical trial?

"Candidates who are suffering from acute pain and lie between the ages of 21-65 have the chance to join this medical study. A total of 100 participants will be accepted into the trial."

Answered by AI

Are there any vacancies for prospective participants in this experiment?

"Affirmative. According to the available clinicaltrials.gov information, this research project is currently open for participants and was initially listed on 7th May 2021. The study requires approximately 100 volunteers at two distinct sites, with its last update taking place on 5th December 2022."

Answered by AI

Has Active THC been evaluated in other clinical experiments?

"Currently, 32 studies are exploring Active THC's efficacy. Out of those, 3 have advanced to Phase 3 trials. Hartford is the primary hub for these experiments but 51 other medical centres throughout America are participating as well."

Answered by AI

How many participants are expected to join this research endeavor?

"Confirmed. Clinicaltrials.gov confirms that the search for participants is still underway; this trial was first posted on May 7th 2021 and subsequently edited as recently as December 5th 2022, with a goal of recruiting 100 patients from 2 centres."

Answered by AI

Has this trial been conducted before, or is it a new experiment?

"At present, 32 clinical trials are being conducted across 33 municipalities and 5 different nations to further understand the medicinal effects of Active THC. In 2015, Jazz Pharmaceuticals sponsored a study with 200 participants that successfully passed through Phase 2 & 3 testing. Subsequently, 60 experiments have been carried out over the past five years."

Answered by AI

Who else is applying?

What site did they apply to?
Altman Clinical and Translational Research Institute
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria

Why did patients apply to this trial?

Want cannabis for chronic long lasting pain I do not take anything for pain now except for pregabalin for neuropathy.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Fadel Zeidan 2021. "Brain Mechanisms Supporting Cannabis-induced Pain Relief". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04982965.
All > Acute Pain
~47 spots leftby Jan 2027
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