NVX-CoV2705 Vaccine for COVID-19
(COVID-19 Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, if you are on immunosuppressants or certain immune-modifying drugs, you may need to stop them 90 days before joining the study.
What data supports the effectiveness of the NVX-CoV2705 Vaccine treatment for COVID-19?
Is the NVX-CoV2705 Vaccine safe for humans?
How is the NVX-CoV2705 vaccine different from other COVID-19 treatments?
The NVX-CoV2705 vaccine is unique because it is a recombinant spike protein nanoparticle vaccine, which means it uses a piece of the virus's spike protein to stimulate an immune response. This is different from mRNA vaccines, which use genetic material to instruct cells to produce the spike protein. Additionally, it includes an adjuvant (a substance that enhances the body's immune response) called Matrix-M, which helps boost its effectiveness.12389
What is the purpose of this trial?
The present study aims to investigate the safety and immunogenicity of the Novavax JN.1 subvariant vaccine SARS-CoV-2 rS adjuvanted with Matrix-M (NVX CoV2705) in previously vaccinated adults. A descriptive comparison will be made with participants who received the prior authorized vaccine NVX-CoV2601 in an earlier study (2019nCoV-313).
Eligibility Criteria
Adults over 18 who have had at least 3 doses of an approved COVID-19 vaccine, with the last dose given more than 6 months ago. They must be medically stable and not involved in other research that could affect results. Women able to have children must avoid pregnancy or use contraception during the study.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a single dose of the NVX CoV2705 vaccine on Day 0
Immunogenicity Monitoring
Participants are monitored for immunogenicity until Day 28
Safety Follow-up
Participants are monitored for safety data collection up to 180 days post-vaccination
Treatment Details
Interventions
- NVX-CoV2705 Vaccine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Novavax
Lead Sponsor