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Cannabis Abstinence for Cannabis Use Disorder

Phase < 1
Recruiting
Led By Stephen R Baldassarri, M.D.
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and day 28
Awards & highlights

Study Summary

This trial will explore the link between cannabis use disorder, brain activity, and cognitive function to see how they affect each other.

Who is the study for?
This trial is for adults with Cannabis Use Disorder (CUD) who have used cannabis more than 20 times but don't have other substance use disorders or major psychiatric conditions. They must be physically healthy, not pregnant or breastfeeding, and have an IQ over 80. Healthy controls (HC) with no recent cannabis use can also participate.Check my eligibility
What is being tested?
The study investigates how stopping cannabis affects brain chemistry, brain waves, and thinking in people with CUD using PET scans to measure a specific receptor and EEG to monitor brain activity. It compares these findings between regular cannabis users and non-users.See study design
What are the potential side effects?
Potential side effects may include discomfort from abstaining from cannabis for those with CUD. The PET scan involves exposure to a small amount of radiation. MRI imaging might cause discomfort due to the enclosed space or noise during the procedure.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and day 28
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and day 28 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Metabotropic Glutamate Receptor 5 (mGluR5) Availability
Secondary outcome measures
Change in Neurocognitive Function using CogState Cognitive Battery
Change in Verbal Memory measured using Electroencephalography (EEG)

Trial Design

2Treatment groups
Experimental Treatment
Group I: Healthy controlExperimental Treatment1 Intervention
Healthy control participants undergo neuroimaging, cognitive testing, and EEG at baseline.
Group II: Cannabis use disorderExperimental Treatment2 Interventions
CUD participants participants undergo neuroimaging, cognitive testing, and EEG at baseline and following cannabis abstinence at 4 weeks follow-up. Participants will receive motivational enhancement and contingency management during the 4-week abstinence period.

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,848 Previous Clinical Trials
2,737,758 Total Patients Enrolled
National Institute on Drug Abuse (NIDA)NIH
2,468 Previous Clinical Trials
2,619,288 Total Patients Enrolled
Stephen R Baldassarri, M.D.Principal InvestigatorYale University
1 Previous Clinical Trials
15 Total Patients Enrolled

Media Library

Cannabis use disorder Clinical Trial Eligibility Overview. Trial Name: NCT05664763 — Phase < 1
Cannabis Use Disorder Research Study Groups: Cannabis use disorder, Healthy control
Cannabis Use Disorder Clinical Trial 2023: Cannabis use disorder Highlights & Side Effects. Trial Name: NCT05664763 — Phase < 1
Cannabis use disorder 2023 Treatment Timeline for Medical Study. Trial Name: NCT05664763 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I a permissible participant for this clinical research?

"In order to be admitted into this medical trial, the subject must suffer from a cannabis use disorder and fall within the 18-55 years old age bracket. Approximately 60 individuals will receive admittance."

Answered by AI

Is the current research open to those aged eighteen and over?

"Qualified participants must range between 18 and 55. Meanwhile, 15 trials are available for individuals under the age of majority while 49 offer treatment to those 65 or older."

Answered by AI

Does this medical trial have any openings for participants?

"According to information hosted on clinicaltrials.gov, this trial has ceased recruiting patients since its last edit of December 22nd 2022 and is not currently seeking participants. Despite that, there are still 121 other medical studies actively welcoming volunteers for engagement in their trials."

Answered by AI

Who else is applying?

What state do they live in?
Tennessee
Ohio
What portion of applicants met pre-screening criteria?
Did not meet criteria
What site did they apply to?
The Anlyan Center
Recent research and studies
clinicaltrials.govStudy
Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis
Stephen Baldassarri 2023. "Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05664763.
All > Marijuana > Cannabis
~40 spots leftby Feb 2028
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