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Cannabinoid

THC for Cannabis Abuse Effects on Memory and Learning

Phase 1 & 2
Recruiting
Led By Godfrey Pearlson, M.D
Research Sponsored by Hartford Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-55 years old
18-55 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and post drug administration at 10 minutes.
Awards & highlights

Study Summary

This trial will study how THC in cannabis affects various types of memory and learning, compared to placebo.

Who is the study for?
This trial is for English-speaking, right-handed adults aged 18-55 who have used cannabis and felt 'high' in the past two years. It's not for those with a current high tolerance or cravings, any serious medical conditions that affect brain function, left-handedness, history of bad reactions to cannabis, or unsafe MRI candidates.Check my eligibility
What is being tested?
The study tests how THC (the active component in marijuana) affects memory and learning by comparing it to a placebo. Participants will take cognitive tests and undergo fMRI scans to assess the impact of THC on their brain activity.See study design
What are the potential side effects?
Possible side effects may include short-term memory impairment, altered sensory perceptions, changes in mood or behavior during the testing period due to THC's psychoactive properties.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 55 years old.
Select...
I am between 18 and 55 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and post drug administration at 10 minutes.
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and post drug administration at 10 minutes. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Marijuana induced performance changes on Relational and Item Specific Coding (RISE) fMRI Task.
Marijuana induced performance changes on fMRI Monetary Incentive Delay (MID) Task.
Marijuana induced performance changes on fMRI Multi-Stage Decision Making (MSDM) Task.
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Placebo THCExperimental Treatment1 Intervention
Participants will receive placebo THC.
Group II: High Dose THCExperimental Treatment1 Intervention
Participants will receive high dose THC.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo
1995
Completed Phase 3
~2670

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Hartford HospitalLead Sponsor
133 Previous Clinical Trials
18,912 Total Patients Enrolled
Yale UniversityOTHER
1,848 Previous Clinical Trials
2,737,798 Total Patients Enrolled
Godfrey Pearlson, M.DPrincipal InvestigatorYale University
2 Previous Clinical Trials
44 Total Patients Enrolled

Media Library

THC (Cannabinoid) Clinical Trial Eligibility Overview. Trial Name: NCT05116527 — Phase 1 & 2
Tetrahydrocannabinol Research Study Groups: High Dose THC, Placebo THC
Tetrahydrocannabinol Clinical Trial 2023: THC Highlights & Side Effects. Trial Name: NCT05116527 — Phase 1 & 2
THC (Cannabinoid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05116527 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment allow for geriatric participants?

"The parameters of this study necessitates that applicants must be between 18 to 55 years old. Those who are younger than 18 have 19 alternative trails while those over 65 can look into 68 medical trials."

Answered by AI

How many participants have enrolled in this investigation?

"Agreed. Clinicaltrials.gov data indicates that this clinical trial, initially posted on July 7th 2022, is currently recruiting participants. Approximately 20 patients need to be selected from a single medical facility."

Answered by AI

What criteria must be met for individuals to become part of this trial?

"This trial is enrolling 20 participants aged 18 to 55, who are cannabis users and right-handed."

Answered by AI

Is this a pioneering clinical trial?

"Since 2015, the effectiveness of marijuana, hashish, THC and grass has been studied. Jazz Pharmaceuticals kicked off this research journey with a 200-patient trial in that year. After Phase 2 & 3 approval was granted to these substances, 31 active trials for them have come about across 32 cities and 5 nations."

Answered by AI

What previous investigations have been conducted regarding Cannabis derivatives such as Marijuana, Hashish, Tetrahydrocannabinol and Grass?

"Currently, 31 trials examining the efficacy of Marijuana, Hashish, THC and Grass are taking place. Three of these studies have advanced to Phase 3 testing; Hartford Connecticut is hosting most trials for this treatment with a total of 46 sites running experiments."

Answered by AI

Are there vacancies within this research project for volunteers?

"According to the information hosted on clinicaltrials.gov, this medical trial initiated enrollment in July and is still actively seeking volunteers as of August 4th 2022."

Answered by AI

Who else is applying?

What state do they live in?
New York
New Jersey
Connecticut
Other
How old are they?
18 - 65
What site did they apply to?
Hartford Hospital
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Hartford Hospital: < 24 hours
Average response time
  • < 2 Days
~7 spots leftby Apr 2025