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Behavioral Intervention

Memory Enhancement Training for Multiple Sclerosis (STEM Trial)

N/A
Recruiting
Led By Nancy D Chiaravalloti, PhD
Research Sponsored by Kessler Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of Multiple Sclerosis
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
Awards & highlights

STEM Trial Summary

This trial will test if a memory technique can help people with MS.

Who is the study for?
This trial is for left-handed English speakers with Multiple Sclerosis who have learning and memory difficulties. They must not be on certain medications, have had a recent symptom flare-up, substance abuse issues, or significant psychiatric conditions like bipolar disorder or schizophrenia.Check my eligibility
What is being tested?
The study tests the effectiveness of Strategy-Based Training to Enhance Memory (STEM) compared to placebo exercises in improving memory in people with Multiple Sclerosis.See study design
What are the potential side effects?
Since this trial involves cognitive training exercises rather than medication, traditional physical side effects are not expected. However, participants may experience fatigue or frustration during the tasks.

STEM Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with Multiple Sclerosis.

STEM Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Changes in scores on self-report measure of everyday cognition (objective)
Changes in scores on self-report measure of everyday cognition (subjective)
Secondary outcome measures
Changes in ability in spontaneous production of words
Changes in auditory processing speed
Changes in episodic verbal memory and learning
+4 more

STEM Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: ExperimentalExperimental Treatment1 Intervention
The experimental group will receive memory enhancement exercises administered twice a week for 4 weeks (8 training sessions).
Group II: Control groupPlacebo Group1 Intervention
The control group will receive placebo memory enhancement exercises administered twice a week for 4 weeks (8 training sessions).

Find a Location

Who is running the clinical trial?

Kessler FoundationLead Sponsor
173 Previous Clinical Trials
10,588 Total Patients Enrolled
32 Trials studying Multiple Sclerosis
1,497 Patients Enrolled for Multiple Sclerosis
Nancy D Chiaravalloti, PhDPrincipal InvestigatorKessler Foundation
4 Previous Clinical Trials
201 Total Patients Enrolled
2 Trials studying Multiple Sclerosis
108 Patients Enrolled for Multiple Sclerosis

Media Library

Strategy-Based Training to Enhance Memory (STEM) (Behavioral Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT03983681 — N/A
Multiple Sclerosis Research Study Groups: Experimental, Control group
Multiple Sclerosis Clinical Trial 2023: Strategy-Based Training to Enhance Memory (STEM) Highlights & Side Effects. Trial Name: NCT03983681 — N/A
Strategy-Based Training to Enhance Memory (STEM) (Behavioral Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03983681 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many individuals are permitted to join the experiment?

"Affirmative. According to information provided on clinicaltrials.gov, this trial was initially posted in late September of 2019 and has been actively recruiting since then. The research team is searching for 120 participants spread across 2 locations."

Answered by AI

What are the core goals of this medical experiment?

"This clinical trial will track patient progress before (week 1), immediately after the intervention (week 6) and over time during a long-term follow up period (6 months post-intervention). The primary outcome measure is Changes in scores on self-report measures of everyday cognition. Secondary outcomes include changes to information processing speed as measured by Symbol Digit Modalities Test, visuospatial memory through Brief Visuospatial Memory Test - Revised, and episodic verbal memory/learning with California Verbal Learning Test - 2nd Edition."

Answered by AI

Does my profile satisfy the criteria for this medical experiment?

"In order to be eligible for this medical study, applicants must have a diagnosis of multiple sclerosis and fall between 18-59 years old. A total of 120 participants are needed for completion."

Answered by AI

Are there any vacancies still available for this research initiative?

"Affirmative. According to the information on clinicaltrials.gov, this experiment is actively enlisting participants and was first posted in September of 2019 with an update made in April 2020. The trial seeks 120 patients over 2 sites."

Answered by AI

Is the cutoff age for this trial higher than thirty years old?

"This research is open to those of legal age and younger than 59 years, who meet the eligibility criteria."

Answered by AI

Who else is applying?

What state do they live in?
New Jersey
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
0
Recent research and studies
clinicaltrials.govStudy
Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS
2019. "Evaluation of a Theory-Driven Manualized Approach to Improving New Learning and Memory in MS". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03983681.
All > Memory > Multiple Sclerosis
~17 spots leftby Feb 2025
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