Exercise and Prehabilitation for Kidney Failure, Chronic
This study is evaluating whether a pre-operative exercise program can improve physical functioning in people with CKD and ESRD.
See full descriptionAbout the trial for Kidney Failure, Chronic
Treatment Groups
This trial involves 2 different treatments. Exercise And Prehabilitation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
Eligibility
This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Exercise and Prehabilitation will improve 9 primary outcomes and 1 secondary outcome in patients with Kidney Failure, Chronic. Measurement will happen over the course of Change from 1 week following kidney transplant to 30 and 90 days post operatively..
Who is running the study
Principal InvestigatorPatient Q & A Section
Can kidney failure, chronic be cured?
Patients in the long term with chronic kidney failure may be in a reversible or stable phase, with few signs of disease progression. This suggests that irreversible damage may be averted or irreversible damage is slow to progress (for example, where irreversible damage is done late in the disease process).
What are the signs of kidney failure, chronic?
The main signs of kidney failure, chronic are fatigue, nausea and vomiting, loss of the ability to urinate, and loss of appetite. The most common symptom is fatigue. It is important to differentiate the different types of kidney failure if the person presents with any of the symptoms.
Has exercise and prehabilitation proven to be more effective than a placebo?
Patients enrolled in exercise training and a prehabilitation program had a significant improvement in maximal oxygen uptake and a trend toward reduced VEGF compared with those receiving a placebo. These trials and additional studies conducted in the future are necessary to more clearly ascertain the potential benefits of prehabilitation and exercise training on the evolution of PCT.
What is kidney failure, chronic?
This article briefly addresses the epidemiology and presentation of chronic kidney disease, which also addresses the most salient and significant questions of those who do encounter kidney failure. This article is part of an online textbook and serves to provide a concise, yet informative overview of the diagnosis and treatment of chronic kidney disease. This article is also designed to raise awareness and understanding of chronic kidney disease by providing simple definitions and discussing the impact and impact of chronic kidney disease on several aspects of life. It is a prerequisite for patients to be aware of the disease and to have an appropriate decision-making process in the event of this stage of chronic kidney disease.
What are common treatments for kidney failure, chronic?
As chronic kidney disease (CKD) is a global issue, the results of this study are of great interest. Chronic dialysis is the only treatment for CKD. The present research shows that some of the drugs used for CKD are contraindicated for heart failure. It may be an important target for future research to find out the pharmacokinetic/pharmacodynamic interaction between medications and heart failure. Also, some common treatments for heart failure seem to have a negative impact on CKD. Therefore, it will be necessary to do more research on CKD and heart failure treatment. More specific studies between pharmacokinetics of heart failure drugs and CKD will help clinicians to prevent unwanted side effects of drugs for heart failure.
How many people get kidney failure, chronic a year in the United States?
Approximately 1 million people in the United States have chronic kidney disease (CKD), and more than 25,000, will begin dialysis in 2011. The age-adjusted death rate associated with CKD in children and adults approached that for cancer. Although the age-adjusted death rate for children declined at the beginning of the 2000s, it began to rise again. A similar pattern of age-adjusted death was observed for adults.
What causes kidney failure, chronic?
The most common causes of acute and chronic kidney failure are identifiable in approximately 25% of patients, but many other causes exist which have not yet been documented. They are a challenge for the nephrologist, who has to make a diagnosis and prescribe a treatment for a condition that was not previously known to result in chronic kidney failure. The aim of our study has been to identify these common causes which the nephrologist should be made aware of.
What are the common side effects of exercise and prehabilitation?
Results from a recent clinical trial support the potential to increase the amount and timing of exercise by a small increase in exercise time per day to the time needed to maintain fitness. Although increased exercise to the threshold of training of cardiovascular and muscle system conditioning may maximize the benefits of prehabilitation, it is possible to maximize the benefits of exercise by increasing the time of performing exercise before the conditioning components of exercise are complete. However, further studies are needed to investigate the effect of the amount of exercise per time period on the time to full recovery of the body.
Does kidney failure, chronic run in families?
Findings from a recent study suggest that the occurrence of kidney failure, chronic in a family reflects the existence of an environmental agent predisposing to progression of renal conditions.
What does exercise and prehabilitation usually treat?
Exercise with or without prehabilitation is commonly used to treat chronic kidney disease patients, in addition to patient education and diet. However, with an increasing incidence of chronic kidney disease, exercise with or without prehabilitation could be used as an important treatment of chronic kidney disease.
Is exercise and prehabilitation typically used in combination with any other treatments?
Patients with end-stage kidney disease typically receive various prescription therapies to manage their CKD, which is often difficult to obtain from physicians. Exercise and prehabilitation are commonly applied. The efficacy and safety of combining exercise and prehabilitation with pharmaceutical agents for the treatment of CKD are still uncertain. Exercise programs may help reduce CKD-related progression through a synergistic effect on renal function. prehabilitation and pre-renal-failure CKD management should be assessed as a multiphase treatment strategy through a randomized controlled trial.
What are the latest developments in exercise and prehabilitation for therapeutic use?
A variety of rehabilitation exercises are used in prehospitalization with an effort towards promoting recovery of patients' exercise performance. However, the most important factors for successful rehabilitation appear to be early patient's participation in rehabilitation. Prehospital patients should be educated on their disease trajectory and the possibility of recovery, so they are not only unable to adequately recover during transportation, but they also cannot adequately participate in rehabilitation after admission to hospital. Therefore, it is strongly suggested that an early start to rehabilitation is strongly needed for optimal recovery of patients.