Home-Based Exercise for Chronic Kidney Disease

No longer recruiting at 1 trial location

Overseen By Merin Thomas

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Baylor College of Medicine

Disqualifiers: Pulmonary disease, Angina, Heart failure, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether a simple home exercise program can improve physical function for individuals awaiting a kidney transplant. The main goal is to determine if exercise can enhance health, increase strength, and reduce hospital visits. This trial targets those with chronic kidney disease who feel weak or frail. Participants will follow an 8-week home-based exercise program to assess its impact on daily life and health. As an unphased trial, this study provides a unique opportunity for patients to contribute to understanding how exercise can enhance health and well-being before a kidney transplant.

Do I have to stop taking my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this home-based exercise program is safe for kidney transplant candidates?

Research has shown that home-based exercise programs are generally safe for people with chronic kidney disease. In eight different studies, researchers reported no harmful effects. This finding reassures those considering participation in an 8-week home exercise program trial. These programs typically focus on aerobic activities, which can enhance physical strength and overall well-being without causing harm. Overall, evidence suggests that this type of exercise program is well-tolerated and safe for individuals with chronic conditions. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike the standard care for chronic kidney disease, which often involves medication and dietary changes, this innovative approach utilizes a home-based exercise program. Researchers are excited about this method because it empowers patients to take an active role in their health from the comfort of their own homes. By incorporating regular physical activity, the program aims to improve overall kidney function and quality of life, potentially offering a low-cost, accessible alternative to traditional treatments.

What evidence suggests that home-based exercise is effective for improving physical function in kidney transplant candidates?

Research has shown that exercising at home can help people with chronic kidney disease (CKD) improve mobility. One study found that a home exercise program enhanced the physical abilities of patients with advanced CKD. Exercise is also known to slow the progression of CKD and improve quality of life for those with the disease. Other studies have demonstrated that exercise can boost physical strength and overall health. This trial will evaluate an 8-week home-based exercise program, which may benefit individuals awaiting a kidney transplant by enhancing their physical abilities and well-being. ^{2 3 6 7 8}

Who Is on the Research Team?

Elizabeth C Lorenz, MD

Principal Investigator

Baylor College of Medicine

Are You a Good Fit for This Trial?

This trial is for adults over 18 with any stage of chronic kidney disease who are frail or pre-frail, as measured by specific criteria. They must be able to consent to research and pass a submaximal exercise test if not approved for kidney transplantation. Those with severe heart, lung conditions, or needing multiple organ transplants cannot join.

Inclusion Criteria

Consenting to research

I am considered frail or almost frail based on my health assessment.

I have chronic kidney disease.

Exclusion Criteria

I failed the exercise test and am not approved for a kidney transplant.

I am under 18 years old.

I have serious health issues like heart problems or need for constant oxygen.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2 weeks

1 visit (in-person)

Exercise Intervention

Participants complete an 8-week home-based exercise program with pedal exerciser and resistance bands, including weekly phone calls with an exercise physiologist

8 weeks

Weekly phone calls

Follow-up

Participants are monitored for changes in physical function, frailty, and quality of life after the exercise intervention

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• 8 week home-based exercise program

Trial Overview The study tests an 8-week home-based exercise program's effectiveness in improving physical function, frailty parameters, SPPB scores (a measure of balance and mobility), quality of life, activity levels, and reducing hospitalizations among kidney transplant candidates.

How Is the Trial Designed?

Group I: Intervention Experimental Treatment 1 Intervention

Participants will be asked to complete an 8-week home-based exercise intervention

Who Is Running the Clinical Trial?

Baylor College of Medicine

Lead Sponsor

Trials

1,044

Recruited

6,031,000+

National Institutes of Health (NIH)

Collaborator

Trials

2,896

Recruited

8,053,000+

Mayo Clinic

Collaborator

Trials

3,427

Recruited

3,221,000+

Citations

1. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/36453565/

A nurse-led home-based exercise program for patients with ... The implementation of a home-based exercise program results in improved functional capacity in patients with CKD stage 5.

2. clinicaltrials.gov clinicaltrials.gov/study/NCT03621176

Home-based Exercise in Chronic Kidney Disease The aim of the study is to assess the effectiveness of home-based exercise to improve strength, physical function, health-related quality of life, cognitive ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S246802492401862X

Review of Exercise Interventions to Improve Clinical ... The potential benefits of exercise training in CKD range from slowing disease progression to improving comorbidities and quality of life.

4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11743718/

The impact of different exercise modalities on chronic kidney ... This study sought to summarize the effects of different exercise modalities on the main outcomes impacted by CKD.

5. kireports.org kireports.org/article/S2468-0249(24)01862-X/fulltext

Review of Exercise Interventions to Improve Clinical ... The potential benefits of exercise training in CKD range from slowing disease progression to improving comorbidities and quality of life.

6. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/35635247/

Home-based exercise programs in patients with chronic ... Results: Eight studies were included, none of which reported any adverse effects. The intervention was usually aerobic, 76% of these programs ...

7. sciencedirect.com sciencedirect.com/science/article/abs/pii/S0272638614012803

Exercise Training in CKD: Efficacy, Adherence, and Safety The findings from the present study suggest that an exercise program that includes a supervised and home-based training phase is effective, adhered to, and safe ...

8. bmcnephrol.biomedcentral.com bmcnephrol.biomedcentral.com/articles/10.1186/s12882-021-02618-1

Clinical practice guideline exercise and lifestyle in chronic ... Impact of home-based aerobic exercise on the physical capacity of overweight patients with chronic kidney disease. Int Urol Nephrol. 2015;47 ...