This trial will test whether montelukast can reduce markers of inflammation and cartilage degradation in people who have undergone ACL reconstruction, specifically targeting those with additional meniscal injuries who are at greater risk of rapid cartilage degradation.
- Posttraumatic Osteoarthritis
- Meniscus Tears
- Anterior Cruciate Ligament Injury
4 Primary · 0 Secondary · Reporting Duration: Change between Visit 4 (4 weeks post surgery) and Visit 6 (1 year post surgery)
Side Effects for
2 Treatment Groups
1 of 2
1 of 2
30 Total Participants · 2 Treatment Groups
Primary Treatment: Montelukast · Has Placebo Group · Phase < 1
Who is running the clinical trial?
Age 25 - 50 · All Participants · 3 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
- Jacobs, Cale A., Caitlin E. W. Conley, Virginia Byers Kraus, Drew A. Lansdown, Brian C. Lau, Xiaojuan Li, Sharmila Majumdar, Kurt P. Spindler, Nicole G. Lemaster, and Austin V. Stone. 2022. “Montelukast as a Potential Chondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial): Study Protocol for a Double-blind, Randomized, Placebo-controlled Clinical Trial”. Trials. Springer Science and Business Media LLC. doi:10.1186/s13063-021-05982-3.
- Austin V Stone 2021. "MOntelukast as a Potential CHondroprotective Treatment Following Anterior Cruciate Ligament Reconstruction (MOCHA Trial)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04572256.
Frequently Asked Questions
Are octogenarians permitted to partake in this clinical investigation?
"This clinical study is searching for qualified participants aged between 25 and 50 years old." - Anonymous Online Contributor
Who fulfills the eligibility criteria for this clinical trial?
"To qualify as a potential participant in this clinical trial, individuals must have been diagnosed with degenerative polyarthritis and be between 25 and 50 years old. The total capacity for the study is 30 patients." - Anonymous Online Contributor
What is the upper limit of participants in this clinical examination?
"Affirmative. Evidence from clinicaltrials.gov reveals that this medical trial, which initiated recruitment on February 1st 2021, is currently seeking volunteers to join the experiment. The research requires 30 participants based at a single site." - Anonymous Online Contributor
For what conditions is Montelukast usually prescribed?
"Montelukast is effective at managing exercise-induced bronchospasm, perennial allergic rhinitis (PAR), seasonal allergies and asthma." - Anonymous Online Contributor
To what other research studies has Montelukast been applied?
"Currently, there are 22 active clinical trials of montelukast with 6 of these studies in phase 3. Of the 221 trial sites across the globe, several have been established in Lexington, Kentucky." - Anonymous Online Contributor
Are recruitment efforts ongoing for this clinical trial?
"Confirmed, clinicaltrials.gov currently lists this trial as actively recruiting participants. The project was initially announced on February 1st 2021 and has been updated most recently on September 12th 2022." - Anonymous Online Contributor