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Dietary Intervention for Pancreatic Cancer

N/A
Recruiting
Led By ZhaoPing Li
Research Sponsored by Jonsson Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Life expectancy of greater than 3 months and a Karnofsky performance score of 60 or more
Adults >= 18 years old male or female
Must not have
Ascites requiring paracentesis for symptom improvement
Uncontrolled nausea and vomiting
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to after 12 weeks
Awards & highlights
No Placebo-Only Group

Summary

This trial involves checking for poor nutrition and providing personalized diet plans and regular support to patients with pancreatic cancer that cannot be surgically removed. The goal is to improve their quality of life by ensuring they get the right nutrients.

Who is the study for?
This trial is for adults over 18 with unresectable pancreatic cancer, who are either not on chemotherapy, starting their first cycle, or have been through more than one cycle but still have a life expectancy of over 6 months. They should be able to perform daily activities (Karnofsky score ≥60) and live longer than 3 months.
What is being tested?
The study tests if screening patients for malnutrition and providing dietary support improves quality of life compared to standard care. It involves best practices in nutrition, medical chart reviews, questionnaires, using medical devices to assess nutrition status, and tailored dietary interventions.
What are the potential side effects?
Since the intervention focuses on nutritional assessment and support rather than medication or invasive procedures, side effects may be minimal. However, changes in diet can sometimes cause digestive discomfort or allergic reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am expected to live more than 3 months and can care for myself with some assistance.
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I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I need a procedure to remove fluid from my abdomen to relieve symptoms.
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I frequently experience severe nausea and vomiting that is not managed by medication.
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My creatinine level is above the normal range.
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I am experiencing pain that my current medication cannot control.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~after 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and after 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Average daily steps
Calorie intake from Myfitness Pal
Frequency of hospitalizations
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ARM II (Dietary intervention)Experimental Treatment5 Interventions
Patients undergo malnutrition screening with a registered dietician at baseline and participate in 12 weekly nutrition support sessions and those at moderate to high risk for malnutrition receive a personalized diet prescription on study. Patients also record dietary intake and physical activity using Myfitness Pal smartphone application on study.
Group II: ARM I (Standard of care)Active Control4 Interventions
Patients receive standard nutrition care and record dietary intake and physical activity using Myfitness Pal smartphone application on study.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for pancreatic cancer include chemotherapy, radiation therapy, and targeted therapies. However, for patients with unresectable pancreatic cancer, malnutrition screening and dietary interventions are crucial. These interventions aim to improve nutritional status and quality of life by addressing the severe weight loss and weakness often experienced by these patients. Behavioral techniques help patients modify their reactions to environmental triggers that cause negative reactions, such as nausea and vomiting, while nutritional support provides essential nutrients to combat malnutrition. This approach is vital as it can enhance the patient's overall well-being, potentially improve treatment tolerance, and extend survival.

Find a Location

Who is running the clinical trial?

Jonsson Comprehensive Cancer CenterLead Sponsor
370 Previous Clinical Trials
35,094 Total Patients Enrolled
Silicon Valley Community FoundationUNKNOWN
3 Previous Clinical Trials
548 Total Patients Enrolled
ZhaoPing LiPrincipal InvestigatorUCLA / Jonsson Comprehensive Cancer Center
~8 spots leftby Jan 2025